Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-5871
Authors: | Hahad, Omar Wild, Philipp S. Prochaska, Jürgen H. Schulz, Andreas Lackner, Karl J. Pfeiffer, Norbert Schmidtmann, Irene Michal, Matthias Beutel, Manfred Daiber, Andreas Münzel, Thomas |
Title: | Midregional pro atrial natriuretic peptide : a novel important biomarker for noise annoyance-induced cardiovascular morbidity and mortality? |
Online publication date: | 25-May-2021 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | BACKGROUND Environmental noise exposure has been associated with increased cardiovascular morbidity and mortality. Recently, noise annoyance was shown to induce atrial fibrillation, which was accompanied by significantly increased levels of midregional pro atrial natriuretic peptide (MR-proANP). Therefore, the aim of the present study was to analyze the association between noise annoyance, MR-proANP, incident cardiovascular events, and all-cause mortality. METHODS Levels of MR-proANP were measured in the first 5000 participants of the population-based Gutenberg Health Study. Annoyance was assessed separately for aircraft, road traffic, railway, neighborhood, and industrial/construction noise during the day and sleep. RESULTS In cross-sectional analyses, aircraft noise annoyance during day and sleep, industrial/construction noise annoyance during day, and railway noise annoyance during sleep were independently associated with increased levels of MR-proANP after multivariable adjustment. After a 5-year follow-up period, there were 43 cases of incident atrial fibrillation and 103 of incident cardiovascular disease (comprising atrial fibrillation, coronary artery disease, myocardial infarction, heart failure, or stroke). Moreover, there were 301 deaths after a mean follow-up of 7.42 ± 1.66 years. An odds ratio (OR) of 2.82 ([95% confidence interval (CI) 1.86; 4.35], p < 0.0001) for incident atrial fibrillation and an OR of 1.49 ([95% CI 1.13; 1.96], p = 0.0046) for incident cardiovascular disease per 1-standard deviation (SD) increase in MR-proANP levels were found. A 36% (hazard ratio: 1.36 [95% CI 1.19; 1.55], p < 0.0001) higher risk of death was found per 1-SD increase in MR-proANP levels. CONCLUSIONS Noise annoyance may contribute to cardiovascular morbidity and mortality and is characterized by increased levels of MR-proANP. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-5871 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Clinical research in cardiology 110 |
Pages or article number: | 29 39 |
Publisher: | Springer |
Publisher place: | Berlin |
Issue date: | 2021 |
ISSN: | 1861-0692 |
Publisher URL: | https://doi.org/10.1007/s00392-020-01645-6 |
Publisher DOI: | 10.1007/s00392-020-01645-6 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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hahad_omar-midregional_pr-20210430213311396.pdf | 1.23 MB | Adobe PDF | View/Open |