Autoren:	Hahad, Omar Wild, Philipp S. Prochaska, Jürgen H. Schulz, Andreas Lackner, Karl J. Pfeiffer, Norbert Schmidtmann, Irene Michal, Matthias Beutel, Manfred Daiber, Andreas Münzel, Thomas
Titel:	Midregional pro atrial natriuretic peptide : a novel important biomarker for noise annoyance-induced cardiovascular morbidity and mortality?
Online-Publikationsdatum:	25-Mai-2021
Erscheinungsdatum:	2021
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	BACKGROUND Environmental noise exposure has been associated with increased cardiovascular morbidity and mortality. Recently, noise annoyance was shown to induce atrial fibrillation, which was accompanied by significantly increased levels of midregional pro atrial natriuretic peptide (MR-proANP). Therefore, the aim of the present study was to analyze the association between noise annoyance, MR-proANP, incident cardiovascular events, and all-cause mortality. METHODS Levels of MR-proANP were measured in the first 5000 participants of the population-based Gutenberg Health Study. Annoyance was assessed separately for aircraft, road traffic, railway, neighborhood, and industrial/construction noise during the day and sleep. RESULTS In cross-sectional analyses, aircraft noise annoyance during day and sleep, industrial/construction noise annoyance during day, and railway noise annoyance during sleep were independently associated with increased levels of MR-proANP after multivariable adjustment. After a 5-year follow-up period, there were 43 cases of incident atrial fibrillation and 103 of incident cardiovascular disease (comprising atrial fibrillation, coronary artery disease, myocardial infarction, heart failure, or stroke). Moreover, there were 301 deaths after a mean follow-up of 7.42 ± 1.66 years. An odds ratio (OR) of 2.82 ([95% confidence interval (CI) 1.86; 4.35], p < 0.0001) for incident atrial fibrillation and an OR of 1.49 ([95% CI 1.13; 1.96], p = 0.0046) for incident cardiovascular disease per 1-standard deviation (SD) increase in MR-proANP levels were found. A 36% (hazard ratio: 1.36 [95% CI 1.19; 1.55], p < 0.0001) higher risk of death was found per 1-SD increase in MR-proANP levels. CONCLUSIONS Noise annoyance may contribute to cardiovascular morbidity and mortality and is characterized by increased levels of MR-proANP.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5871
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Clinical research in cardiology 110
Seitenzahl oder Artikelnummer:	29 39
Verlag:	Springer
Verlagsort:	Berlin
Erscheinungsdatum:	2021
ISSN:	1861-0692
URL der Originalveröffentlichung:	https://doi.org/10.1007/s00392-020-01645-6
DOI der Originalveröffentlichung:	10.1007/s00392-020-01645-6
Enthalten in den Sammlungen:	JGU-Publikationen