Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5868
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dc.contributor.authorSelt, Maximilian-
dc.contributor.authorGleede, Barbara-
dc.contributor.authorFranke, Robert-
dc.contributor.authorStenglein, Andreas-
dc.contributor.authorWaldvogel, Siegfried R.-
dc.date.accessioned2021-05-19T10:23:33Z-
dc.date.available2021-05-19T10:23:33Z-
dc.date.issued2021-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/5877-
dc.description.abstract3,3′,5,5’-Tetramethyl-2,2′-biphenol is well known as an outstanding building block for ligands in transition-metal catalysis and is therefore of particular industrial interest. The electro-organic method is a powerful, sustainable, and efficient alternative to conventional synthetic approaches to obtain symmetric and non-symmetric biphenols. Here, we report the successive scale-up of the dehydrogenative anodic homocoupling of 2,4-dimethylphenol (4) from laboratory scale to the technically relevant scale in highly modular narrow gap flow electrolysis cells. The electrosynthesis was optimized in a manner that allows it to be easily adopted to different scales such as laboratory, semitechnical and technical scale. This includes not only the synthesis itself and its optimization but also a work-up strategy of the desired biphenols for larger scale. Furthermore, the challenges such as side reactions, heat development and gas evolution that arose during optimization are also discussed in detail. We have succeeded in obtaining yields of up to 62% of the desired biphenol.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleElectrosynthesis of 3,3′,5,5’-tetramethyl-2,2′-biphenol in flowen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-5868-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.de
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleJournal of Flow Chemistryde
jgu.journal.volume11de
jgu.pages.start143de
jgu.pages.end162de
jgu.publisher.year2021-
jgu.publisher.nameSpringer Verlagde
jgu.publisher.urihttps://doi.org/10.1007/s41981-020-00121-6de
jgu.publisher.issn2063-0212de
jgu.organisation.placeMainz-
jgu.subject.ddccode540de
jgu.publisher.doi10.1007/s41981-020-00121-6
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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