Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5863
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dc.contributor.authorWagner, Willi L.-
dc.contributor.authorFöhst, Sonja-
dc.contributor.authorHock, Jessica-
dc.contributor.authorKim, Yong Ook-
dc.contributor.authorPopov, Yury-
dc.contributor.authorSchuppan, Detlef-
dc.contributor.authorSchladitz, Katja-
dc.contributor.authorRedenbach, Claudia-
dc.contributor.authorAckermann, Maximilian-
dc.date.accessioned2021-05-19T10:00:34Z-
dc.date.available2021-05-19T10:00:34Z-
dc.date.issued2021-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/5872-
dc.description.abstractCirrhosis describes the development of excess fibrous tissue around regenerative nodules in response to chronic liver injury and usually leads to irreversible organ damage and end-stage liver disease. During the development of cirrhosis, the formation of collagenous scar tissue is paralleled by a reorganization and remodeling of the hepatic vascular system. To date, macrovascular remodeling in various cirrhosis models has been examined using three-dimensional (3D) imaging modalities, while microvascular changes have been studied mainly by two-dimensional (2D) light microscopic and electron microscopic imaging. Here, we report on the application of high-resolution 3D synchrotron radiation-based microtomography (SRμCT) for the study of the sinusoidal and capillary blood vessel system in three murine models of advanced parenchymal and biliary hepatic fibrosis. SRμCT facilitates the characterization of microvascular architecture and identifies features of intussusceptive angiogenesis in progressive liver fibrosis in a non-destructive 3D manner.en_GB
dc.language.isoengde
dc.rightsCC-BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.title3D analysis of microvasculature in murine liver fibrosis models using synchrotron radiation-based microtomographyen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-5863-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleAngiogenesisde
jgu.journal.volume24de
jgu.pages.start57de
jgu.pages.end65de
jgu.publisher.year2021-
jgu.publisher.nameSpringer Science + Business Media B.V.de
jgu.publisher.placeDordrecht u.a.de
jgu.publisher.urihttps://doi.org/10.1007/s10456-020-09751-9de
jgu.publisher.issn1573-7209de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
Appears in collections:JGU-Publikationen

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