Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-5828
Authors: | Rojas-Charry, Liliana Nardi, Leonardo Methner, Axel Schmeisser, Michael J. |
Title: | Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders |
Online publication date: | 29-Apr-2021 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Autism spectrum disorder (ASD) is a neurodevelopmental condition primarily characterized by an impairment of social interaction combined with the occurrence of repetitive behaviors. ASD starts in childhood and prevails across the lifespan. The variability of its clinical presentation renders early diagnosis difficult. Mutations in synaptic genes and alterations of mitochondrial functions are considered important underlying pathogenic factors, but it is obvious that we are far from a comprehensive understanding of ASD pathophysiology. At the synapse, mitochondria perform diverse functions, which are clearly not limited to their classical role as energy providers. Here, we review the current knowledge about mitochondria at the synapse and summarize the mitochondrial disturbances found in mouse models of ASD and other ASD-related neurodevelopmental disorders, like DiGeorge syndrome, Rett syndrome, Tuberous sclerosis complex, and Down syndrome. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-5828 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Journal of molecular medicine 99 |
Pages or article number: | 161 178 |
Publisher: | Springer |
Publisher place: | Berlin u.a. |
Issue date: | 2021 |
ISSN: | 1432-1440 |
Publisher URL: | https://doi.org/10.1007/s00109-020-02018-2 |
Publisher DOI: | 10.1007/s00109-020-02018-2 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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rojas-charry_liliana-abnormalities_-20210423151435856.pdf | 1.45 MB | Adobe PDF | View/Open |