Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5828
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dc.contributor.authorRojas-Charry, Liliana-
dc.contributor.authorNardi, Leonardo-
dc.contributor.authorMethner, Axel-
dc.contributor.authorSchmeisser, Michael J.-
dc.date.accessioned2021-04-29T11:08:42Z-
dc.date.available2021-04-29T11:08:42Z-
dc.date.issued2021-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/5837-
dc.description.abstractAutism spectrum disorder (ASD) is a neurodevelopmental condition primarily characterized by an impairment of social interaction combined with the occurrence of repetitive behaviors. ASD starts in childhood and prevails across the lifespan. The variability of its clinical presentation renders early diagnosis difficult. Mutations in synaptic genes and alterations of mitochondrial functions are considered important underlying pathogenic factors, but it is obvious that we are far from a comprehensive understanding of ASD pathophysiology. At the synapse, mitochondria perform diverse functions, which are clearly not limited to their classical role as energy providers. Here, we review the current knowledge about mitochondria at the synapse and summarize the mitochondrial disturbances found in mouse models of ASD and other ASD-related neurodevelopmental disorders, like DiGeorge syndrome, Rett syndrome, Tuberous sclerosis complex, and Down syndrome.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleAbnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disordersen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-5828-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleJournal of molecular medicinede
jgu.journal.volume99de
jgu.pages.start161de
jgu.pages.end178de
jgu.publisher.year2021-
jgu.publisher.nameSpringerde
jgu.publisher.placeBerlin u.a.de
jgu.publisher.urihttps://doi.org/10.1007/s00109-020-02018-2de
jgu.publisher.issn1432-1440de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1007/s00109-020-02018-2
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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