Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5827
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dc.contributor.authorLabenz, Christian-
dc.contributor.authorKostev, Karel-
dc.contributor.authorKaps, Leonard-
dc.contributor.authorGalle, Peter R.-
dc.contributor.authorSchattenberg, Jörn M.-
dc.date.accessioned2021-08-26T10:15:00Z-
dc.date.available2021-08-26T10:15:00Z-
dc.date.issued2021-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/5836-
dc.description.abstractDementia and NAFLD are two frequent conditions that share underlying risk factors mainly in the realm of metabolic disease. Additionally, an association between NAFLD and brain aging has been proposed. Therefore, we investigated the hypothesis if NAFLD is an independent risk factor for emerging dementia. In this population-based cohort study, elderly patients (≥ 65 years) with NAFLD diagnosed between 2000 and 2015 were matched 1:1 to a cohort without NAFLD based on ICD-10 coding in the Disease Analyzer database. Matching criteria were age, sex, physician, index year, and co-diagnoses associated with dementia. The primary outcomes of this study were all-cause dementia diagnoses, the incidence of vascular dementia, and antidementive drug prescription. A total of 22,317 patients with NAFLD were matched to 22,317 patients without NAFLD. Within 10 years of the index date, 16.0% of patients with NAFLD and 15.6% of the patients without NAFLD were diagnosed with dementia. On Cox regression analysis, there is no association between NAFLD and the incidence of all-cause dementia (HR 0.97, 95% CI 0.92–1.04), vascular dementia (HR 0.89, 95% CI 0.78–1.02), or the new prescription of antidementive therapy (HR 0.87, 95% CI 0.76–1.01). In sensitivity analyses, there was no association between NAFLD and dementia in different age-groups as well as men or women. In conclusion, in this database study of elderly patients coded with NAFLD no independent association with incident dementia was detected. Risk assessment regarding dementia in patients with NAFLD should be carried out in the same way as for metabolic burdened patients.en_GB
dc.language.isoengde
dc.rightsCC BY-NC*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleIncident dementia in elderly patients with nonalcoholic fatty liver disease in Germanyen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-5827-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleDigestive diseases and sciencesde
jgu.journal.volume66de
jgu.pages.start3179de
jgu.pages.end3185de
jgu.publisher.year2021-
jgu.publisher.nameSpringer Science + Business Media B.V.de
jgu.publisher.placeDordrechtde
jgu.publisher.urihttps://doi.org/10.1007/s10620-020-06644-1de
jgu.publisher.issn1573-2568de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1007/s10620-020-06644-1
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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