Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5750
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dc.contributor.authorNocera, Gianluigi-
dc.contributor.authorJacob, Claire-
dc.date.accessioned2021-05-11T07:45:18Z-
dc.date.available2021-05-11T07:45:18Z-
dc.date.issued2020-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/5759-
dc.description.abstractThe great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), is a critical feature in the context of peripheral nerve regeneration following traumatic injuries and peripheral neuropathies. After a nerve damage, SCs are rapidly activated by injury-induced signals and respond by entering the repair program. During the repair program, SCs undergo dynamic cell reprogramming and morphogenic changes aimed at promoting nerve regeneration and functional recovery. SCs convert into a repair phenotype, activate negative regulators of myelination and demyelinate the damaged nerve. Moreover, they express many genes typical of their immature state as well as numerous de-novo genes. These genes modulate and drive the regeneration process by promoting neuronal survival, damaged axon disintegration, myelin clearance, axonal regrowth and guidance to their former target, and by finally remyelinating the regenerated axon. Many signaling pathways, transcriptional regulators and epigenetic mechanisms regulate these events. In this review, we discuss the main steps of the repair program with a particular focus on the molecular mechanisms that regulate SC plasticity following peripheral nerve injury.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleMechanisms of Schwann cell plasticity involved in peripheral nerve repair after injuryen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-5750-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 10 Biologiede
jgu.organisation.number7970-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleCellular and molecular life sciencesde
jgu.journal.volume77de
jgu.pages.start3977de
jgu.pages.end3989de
jgu.publisher.year2020-
jgu.publisher.nameSpringer Verlagde
jgu.publisher.urihttps://doi.org/10.1007/s00018-020-03516-9de
jgu.publisher.issn1420-9071de
jgu.organisation.placeMainz-
jgu.subject.ddccode570de
jgu.publisher.doi10.1007/s00018-020-03516-9
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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