Gutenberg Open Science: Intramuscular injection of combined calf blood compound (CFC) and homeopathic drug Tr14 accelerates muscle regeneration in vivo

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5092

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DC Field	Value	Language
dc.contributor.author	Belikan, Patrick	-
dc.contributor.author	Nauth, Lisa	-
dc.contributor.author	Färber, Lars-Christopher	-
dc.contributor.author	Abel, Frédéric	-
dc.contributor.author	Langendorf, Eva	-
dc.contributor.author	Drees, Philipp	-
dc.contributor.author	Rommens, Pol M.	-
dc.contributor.author	Ritz, Ulrike	-
dc.contributor.author	Mattyasovszky, Stefan G.	-
dc.date.accessioned	2020-08-28T09:48:59Z	-
dc.date.available	2020-08-28T09:48:59Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5096	-
dc.description.abstract	Skeletal muscle injuries in competitive sports cause lengthy absences of athletes from tournaments. This is of tremendous competitive and economic relevance for both the athletes and their respective clubs. Therapy for structural muscle lesions aims to promote regeneration and fast-track return-to-play. A common clinical treatment strategy for muscle injuries is the intramuscular injection of calf blood compound and the homeopathic drug, Tr14. Although the combination of these two agents was reported to reduce recovery time, the regulatory mechanism whereby this occurs remains unknown. In this in vivo study, we selected a rat model of mechanical muscle injury to investigate the effect of this combination therapy on muscle regeneration. Gene expression analysis and histological images revealed that this combined intramuscular injection for muscle lesions can enhance the expression of pro-myogenic genes and proteins and accelerate muscle regeneration. These findings are novel and depict the positive effects of calf blood compound and the homeopathic drug, Tr14, which are utilized in the field of Sports medicine. Keywords: muscle injury; calf blood compound; homeopathic drug; muscle regeneration; intramuscular injections	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz	de
dc.language.iso	eng	de
dc.rights	CC BY	de_DE
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	-
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Intramuscular injection of combined calf blood compound (CFC) and homeopathic drug Tr14 accelerates muscle regeneration in vivo	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-5092	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	International journal of molecular sciences	de
jgu.journal.volume	21	de
jgu.journal.issue	6	de
jgu.pages.alternative	2112	de
jgu.publisher.year	2020	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/ijms21062112	de
jgu.publisher.issn	1422-0067	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/ijms21062112
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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