Autoren:	Belikan, Patrick Nauth, Lisa Färber, Lars-Christopher Abel, Frédéric Langendorf, Eva Drees, Philipp Rommens, Pol M. Ritz, Ulrike Mattyasovszky, Stefan G.
Titel:	Intramuscular injection of combined calf blood compound (CFC) and homeopathic drug Tr14 accelerates muscle regeneration in vivo
Online-Publikationsdatum:	28-Aug-2020
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Skeletal muscle injuries in competitive sports cause lengthy absences of athletes from tournaments. This is of tremendous competitive and economic relevance for both the athletes and their respective clubs. Therapy for structural muscle lesions aims to promote regeneration and fast-track return-to-play. A common clinical treatment strategy for muscle injuries is the intramuscular injection of calf blood compound and the homeopathic drug, Tr14. Although the combination of these two agents was reported to reduce recovery time, the regulatory mechanism whereby this occurs remains unknown. In this in vivo study, we selected a rat model of mechanical muscle injury to investigate the effect of this combination therapy on muscle regeneration. Gene expression analysis and histological images revealed that this combined intramuscular injection for muscle lesions can enhance the expression of pro-myogenic genes and proteins and accelerate muscle regeneration. These findings are novel and depict the positive effects of calf blood compound and the homeopathic drug, Tr14, which are utilized in the field of Sports medicine. Keywords: muscle injury; calf blood compound; homeopathic drug; muscle regeneration; intramuscular injections
DDC-Sachgruppe:	570 Biowissenschaften 570 Life sciences 610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5092
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	International journal of molecular sciences 21 6
Seitenzahl oder Artikelnummer:	2112
Verlag:	MDPI
Verlagsort:	Basel
Erscheinungsdatum:	2020
ISSN:	1422-0067
URL der Originalveröffentlichung:	https://doi.org/10.3390/ijms21062112
DOI der Originalveröffentlichung:	10.3390/ijms21062112
Enthalten in den Sammlungen:	JGU-Publikationen