Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-4948
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dc.contributor.authorFleischer, Vinzenz-
dc.contributor.authorMuthuraman, Muthuraman-
dc.contributor.authorAnwar, Abdul Rauf-
dc.contributor.authorGonzalez-Escamilla, Gabriel-
dc.contributor.authorRadetz, Angela-
dc.contributor.authorGracien, René-Maxime-
dc.contributor.authorBittner, Stefan-
dc.contributor.authorLüssi, Felix-
dc.contributor.authorMeuth, Sven G.-
dc.contributor.authorZipp, Frauke-
dc.contributor.authorGroppa, Sergiu-
dc.date.accessioned2020-06-29T14:41:16Z-
dc.date.available2020-06-29T16:41:16Z-
dc.date.issued2020-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/4951-
dc.description.abstractEffective connectivity (EC) is able to explore causal effects between brain areas and can depict mechanisms that underlie repair and adaptation in chronic brain diseases. Thus, the application of EC techniques in multiple sclerosis (MS) has the potential to determine directionality of neuronal interactions and may provide an imaging biomarker for disease progression. Here, serial longitudinal structural and resting-state fMRI was performed at 12-week intervals over one year in twelve MS patients. Twelve healthy subjects served as controls (HC). Two approaches for EC quantification were used: Causal Bayesian Network (CBN) and Time-resolved Partial Directed Coherence (TPDC). The EC strength was correlated with the Expanded Disability Status Scale (EDSS) and Fatigue Scale for Motor and Cognitive functions (FSMC). Our findings demonstrated a longitudinal increase in EC between specific brain regions, detected in both the CBN and TPDC analysis in MS patients. In particular, EC from the deep grey matter, frontal, prefrontal and temporal regions showed a continuous increase over the study period. No longitudinal changes in EC were attested in HC during the study. Furthermore, we observed an association between clinical performance and EC strength. In particular, the EC increase in fronto-cerebellar connections showed an inverse correlation with the EDSS and FSMC. Our data depict continuous functional reorganization between specific brain regions indicated by increasing EC over time in MS, which is not detectable in HC. In particular, fronto-cerebellar connections, which were closely related to clinical performance, may provide a marker of brain plasticity and functional reserve in MS.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleContinuous reorganization of cortical information flow in multiple sclerosis : a longitudinal fMRI effective connectivity studyen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.doihttp://doi.org/10.25358/openscience-4948-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 04 Medizin-
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleScientific reports-
jgu.journal.volume10-
jgu.pages.alternativeArt. 806-
jgu.publisher.year2020-
jgu.publisher.nameMacmillan Publishers Limited, part of Springer Nature-
jgu.publisher.placeLondon-
jgu.publisher.urihttp://dx.doi.org/10.1038/s41598-020-57895-x-
jgu.publisher.issn2045-2322-
jgu.organisation.placeMainz-
jgu.subject.ddccode610-
opus.date.accessioned2020-06-29T14:41:16Z-
opus.date.modified2020-07-07T08:36:57Z-
opus.date.available2020-06-29T16:41:16-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 04: Medizin: Forschungszentrum Translationale Neurowissenschaften (FTN)de_DE
opus.identifier.opusid59891-
opus.institute.number0461-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedFleischer, Vinzenz-
opus.affiliatedMuthuraman, Muthuraman-
opus.affiliatedLüssi, Felix-
opus.affiliatedZipp, Frauke-
opus.affiliatedGroppa, Sergiu-
jgu.publisher.doi10.1038/s41598-020-57895-x
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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