Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-4934Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Buono, Andrea | - |
| dc.contributor.author | Mühlenhaus, Annika | - |
| dc.contributor.author | Schäfer, Tabitha | - |
| dc.contributor.author | Trieb, Ann-Kristin | - |
| dc.contributor.author | Schmeißer, Julian | - |
| dc.contributor.author | Koppe, Franziska | - |
| dc.contributor.author | Münzel, Thomas | - |
| dc.contributor.author | Anadol, Remzi | - |
| dc.contributor.author | Gori, Tommaso | - |
| dc.date.accessioned | 2020-06-10T14:12:00Z | - |
| dc.date.available | 2020-06-10T16:12:00Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/4937 | - |
| dc.description.abstract | AIMS: We evaluate feasibility and reproducibility of post hoc quantitative flow ratio (QFR) measurements and their prognostic predictive power during long-term follow-up. METHODS AND RESULTS: Between 2010 and 2012, 167 patients without angiographic evidence of significant stenoses were enrolled in a prospective registry. Of these patients, 96% presented 7 years follow-up data. QFR was measured post hoc by three certified investigators. QFR analysis was feasible in 71% of left anterior descending (LAD), 72% of left circumflex (LCX), and 61% of right (RCA) coronaries for a total of 350 measurements repeated in triplicate. Coefficients of variation were 2.1% for RCA and LCX, and 2.8% for the LAD (quartile coefficients of dispersion respectively 1.5, 1.4, and 1.3). QFR ≤0.80 was recorded in 25 patients (27 vessels, in 74% of the cases LAD). A total of 86 major adverse cardiovascular and cerebrovascular events were observed in 76 patients. QFR ≤0.80 in at least one of the three vessels was the strongest predictor of events (HR 3.14, 95%CI 1.78–5.54, p = 0.0001). This association was maintained in several sensitivity analyses. CONCLUSIONS: QFR reproducibility is acceptable, even when analysis is performed post hoc. A pathological QFR is not rare in patients without angiographic evidence of significant stenosis and is a predictor of incident events during long-term follow-up. Condensed Abstract: In a post hoc analysis of 167 patients without evidence of angiographic significant stenosis, the presence of QFR value ≤0.80 in at least one of the three coronary vessels showed to be the strongest predictor of major adverse cardiovascular and cerebrovascular events during long-term follow-up. QFR reproducibility have been shown to be acceptable among experienced operators. Keywords: fractional flow reserve; coronary artery disease; coronary interventions; Quantitative flow reserve | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | - |
| dc.language.iso | eng | - |
| dc.rights | CC BY | de_DE |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | QFR predicts the incidence of long-term adverse events in patients with suspected CAD : feasibility and reproducibility of the method | en_GB |
| dc.type | Zeitschriftenaufsatz | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-publ-598682 | - |
| dc.identifier.doi | http://doi.org/10.25358/openscience-4934 | - |
| jgu.type.dinitype | article | - |
| jgu.type.version | Published version | en_GB |
| jgu.type.resource | Text | - |
| jgu.organisation.department | FB 04 Medizin | - |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Journal of Clinical Medicine | - |
| jgu.journal.volume | 9 | - |
| jgu.journal.issue | 1 | - |
| jgu.pages.alternative | Art. 220 | - |
| jgu.publisher.year | 2020 | - |
| jgu.publisher.name | MDPI | - |
| jgu.publisher.place | Basel | - |
| jgu.publisher.uri | http://dx.doi.org/10.3390/jcm9010220 | - |
| jgu.publisher.issn | 2077-0383 | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | - |
| opus.date.accessioned | 2020-06-10T14:12:00Z | - |
| opus.date.modified | 2020-07-06T10:13:23Z | - |
| opus.date.available | 2020-06-10T16:12:00 | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 04: Medizin: Kardiologie I | de_DE |
| opus.identifier.opusid | 59868 | - |
| opus.institute.number | 0467 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_GB |
| opus.affiliated | Münzel, Thomas | - |
| opus.affiliated | Gori, Tommaso | - |
| jgu.publisher.doi | 10.3390/jcm9010220 | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
