Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-4934
Authors: | Buono, Andrea Mühlenhaus, Annika Schäfer, Tabitha Trieb, Ann-Kristin Schmeißer, Julian Koppe, Franziska Münzel, Thomas Anadol, Remzi Gori, Tommaso |
Title: | QFR predicts the incidence of long-term adverse events in patients with suspected CAD : feasibility and reproducibility of the method |
Online publication date: | 10-Jun-2020 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | AIMS: We evaluate feasibility and reproducibility of post hoc quantitative flow ratio (QFR) measurements and their prognostic predictive power during long-term follow-up. METHODS AND RESULTS: Between 2010 and 2012, 167 patients without angiographic evidence of significant stenoses were enrolled in a prospective registry. Of these patients, 96% presented 7 years follow-up data. QFR was measured post hoc by three certified investigators. QFR analysis was feasible in 71% of left anterior descending (LAD), 72% of left circumflex (LCX), and 61% of right (RCA) coronaries for a total of 350 measurements repeated in triplicate. Coefficients of variation were 2.1% for RCA and LCX, and 2.8% for the LAD (quartile coefficients of dispersion respectively 1.5, 1.4, and 1.3). QFR ≤0.80 was recorded in 25 patients (27 vessels, in 74% of the cases LAD). A total of 86 major adverse cardiovascular and cerebrovascular events were observed in 76 patients. QFR ≤0.80 in at least one of the three vessels was the strongest predictor of events (HR 3.14, 95%CI 1.78–5.54, p = 0.0001). This association was maintained in several sensitivity analyses. CONCLUSIONS: QFR reproducibility is acceptable, even when analysis is performed post hoc. A pathological QFR is not rare in patients without angiographic evidence of significant stenosis and is a predictor of incident events during long-term follow-up. Condensed Abstract: In a post hoc analysis of 167 patients without evidence of angiographic significant stenosis, the presence of QFR value ≤0.80 in at least one of the three coronary vessels showed to be the strongest predictor of major adverse cardiovascular and cerebrovascular events during long-term follow-up. QFR reproducibility have been shown to be acceptable among experienced operators. Keywords: fractional flow reserve; coronary artery disease; coronary interventions; Quantitative flow reserve |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-4934 |
URN: | urn:nbn:de:hebis:77-publ-598682 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Journal of Clinical Medicine 9 1 |
Pages or article number: | Art. 220 |
Publisher: | MDPI |
Publisher place: | Basel |
Issue date: | 2020 |
ISSN: | 2077-0383 |
Publisher URL: | http://dx.doi.org/10.3390/jcm9010220 |
Publisher DOI: | 10.3390/jcm9010220 |
Appears in collections: | JGU-Publikationen |