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Autoren: Endres, Kristina
Titel: Amyloidogenic peptides in human neuro-degenerative diseases and in microorganisms : a sorrow shared is a sorrow halved?
Online-Publikationsdatum: 10-Jun-2020
Erscheinungsdatum: 2020
Sprache des Dokuments: Englisch
Zusammenfassung/Abstract: The term “amyloid” refers to proteinaceous deposits of peptides that might be generated from larger precursor proteins e.g., by proteolysis. Common to these peptides is a stable cross-β dominated secondary structure which allows self-assembly, leading to insoluble oligomers and lastly to fibrils. These highly ordered protein aggregates have been, for a long time, mainly associated with human neurodegenerative diseases such as Alzheimer’s disease (Amyloid-β peptides). However, they also exert physiological functions such as in release of deposited hormones in human beings. In the light of the rediscovery of our microbial commensals as important companions in health and disease, the fact that microbes also possess amyloidogenic peptides is intriguing. Transmission of amyloids by iatrogenic means or by consumption of contaminated meat from diseased animals is a well-known fact. What if also our microbial commensals might drive human amyloidosis or suffer from our aggregated amyloids? Moreover, as the microbial amyloids are evolutionarily older, we might learn from these organisms how to cope with the sword of Damocles forged of endogenous, potentially toxic peptides. This review summarizes knowledge about the interplay between human amyloids involved in neurodegenerative diseases and microbial amyloids. Keywords: amyloid; Alzheimer’s disease; biofilm; neurodegeneration; microbiota; Parkinson’s disease
DDC-Sachgruppe: 610 Medizin
610 Medical sciences
Veröffentlichende Institution: Johannes Gutenberg-Universität Mainz
Organisationseinheit: FB 04 Medizin
Veröffentlichungsort: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-4877
URN: urn:nbn:de:hebis:77-publ-598661
Version: Published version
Publikationstyp: Zeitschriftenaufsatz
Nutzungsrechte: CC BY
Informationen zu den Nutzungsrechten: https://creativecommons.org/licenses/by/4.0/
Zeitschrift: Molecules
25
4
Seitenzahl oder Artikelnummer: Art. 925
Verlag: MDPI
Verlagsort: Basel
Erscheinungsdatum: 2020
ISSN: 1420-3049
URL der Originalveröffentlichung: http://dx.doi.org/10.3390/molecules25040925
DOI der Originalveröffentlichung: 10.3390/molecules25040925
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