Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-461
Authors: | Sinnes, Jean-Philippe Nagel, Johannes Rösch, Frank |
Title: | AAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177Lu |
Online publication date: | 4-Nov-2019 |
Year of first publication: | 2019 |
Language: | english |
Abstract: | AAZTA (1,4-bis (carboxymethyl)-6-[bis (carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) based chelators were initially developed in the context of magnetic resonance imaging. First radiochemical studies showed the capability of AAZTA to form stable complexes with radiolanthanides and moderately stable complexes with 68Ga. For a systematic comparison of the labelling capabilities with current diagnostic and therapeutic trivalent radiometals, AAZTA5 (1,4-bis (carboxymethyl)-6-[bis (carboxymethyl)]amino-6-[pentanoic-acid]perhydro-1,4-diazepine) was synthesized representing a bifunctional version with a pentanoic acid at the carbon-6 atom. To evaluate the effect of adding a targeting vector (TV) to the bifunctional chelator on the complex formation, AAZTA5-TOC was synthesized, radiolabeled and tested in comparison to the uncoupled AAZTA5. |
DDC: | 540 Chemie 540 Chemistry and allied sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-461 |
URN: | urn:nbn:de:hebis:77-publ-593909 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | EJNMMI radiopharmacy and chemistry 4 |
Pages or article number: | Art. 18 |
Publisher: | SpringerOpen |
Publisher place: | Heidelberg |
Issue date: | 2019 |
ISSN: | 2365-421X |
Publisher URL: | http://dx.doi.org/10.1186/s41181-019-0068-1 |
Publisher DOI: | 10.1186/s41181-019-0068-1 |
Appears in collections: | JGU-Publikationen |