Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-461
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dc.contributor.authorSinnes, Jean-Philippe-
dc.contributor.authorNagel, Johannes-
dc.contributor.authorRösch, Frank-
dc.date.accessioned2019-11-04T10:37:08Z-
dc.date.available2019-11-04T11:37:08Z-
dc.date.issued2019-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/463-
dc.description.abstractAAZTA (1,4-bis (carboxymethyl)-6-[bis (carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) based chelators were initially developed in the context of magnetic resonance imaging. First radiochemical studies showed the capability of AAZTA to form stable complexes with radiolanthanides and moderately stable complexes with 68Ga. For a systematic comparison of the labelling capabilities with current diagnostic and therapeutic trivalent radiometals, AAZTA5 (1,4-bis (carboxymethyl)-6-[bis (carboxymethyl)]amino-6-[pentanoic-acid]perhydro-1,4-diazepine) was synthesized representing a bifunctional version with a pentanoic acid at the carbon-6 atom. To evaluate the effect of adding a targeting vector (TV) to the bifunctional chelator on the complex formation, AAZTA5-TOC was synthesized, radiolabeled and tested in comparison to the uncoupled AAZTA5.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC-BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleAAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177Luen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.urnurn:nbn:de:hebis:77-publ-593909-
dc.identifier.doihttp://doi.org/10.25358/openscience-461-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.-
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleEJNMMI radiopharmacy and chemistry-
jgu.journal.volume4-
jgu.pages.alternativeArt. 18-
jgu.publisher.year2019-
jgu.publisher.nameSpringerOpen-
jgu.publisher.placeHeidelberg-
jgu.publisher.urihttp://dx.doi.org/10.1186/s41181-019-0068-1-
jgu.publisher.issn2365-421X-
jgu.organisation.placeMainz-
jgu.subject.ddccode540-
opus.date.accessioned2019-11-04T10:37:08Z-
opus.date.modified2019-11-04T11:32:38Z-
opus.date.available2019-11-04T11:37:08-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Kernchemiede_DE
opus.identifier.opusid59390-
opus.institute.number0904-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedRösch, Frank-
Appears in collections:JGU-Publikationen

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