Authors:	Sinnes, Jean-Philippe Nagel, Johannes Rösch, Frank
Title:	AAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177Lu
Online publication date:	4-Nov-2019
Year of first publication:	2019
Language:	english
Abstract:	AAZTA (1,4-bis (carboxymethyl)-6-[bis (carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) based chelators were initially developed in the context of magnetic resonance imaging. First radiochemical studies showed the capability of AAZTA to form stable complexes with radiolanthanides and moderately stable complexes with 68Ga. For a systematic comparison of the labelling capabilities with current diagnostic and therapeutic trivalent radiometals, AAZTA5 (1,4-bis (carboxymethyl)-6-[bis (carboxymethyl)]amino-6-[pentanoic-acid]perhydro-1,4-diazepine) was synthesized representing a bifunctional version with a pentanoic acid at the carbon-6 atom. To evaluate the effect of adding a targeting vector (TV) to the bifunctional chelator on the complex formation, AAZTA5-TOC was synthesized, radiolabeled and tested in comparison to the uncoupled AAZTA5.
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-461
URN:	urn:nbn:de:hebis:77-publ-593909
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	EJNMMI radiopharmacy and chemistry 4
Pages or article number:	Art. 18
Publisher:	SpringerOpen
Publisher place:	Heidelberg
Issue date:	2019
ISSN:	2365-421X
Publisher URL:	http://dx.doi.org/10.1186/s41181-019-0068-1
Publisher DOI:	10.1186/s41181-019-0068-1
Appears in collections:	JGU-Publikationen