Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-4092
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dc.contributor.authorFuente Joaniquet, Ana de la
dc.date.accessioned2016-07-25T12:04:18Z
dc.date.available2016-07-25T14:04:18Z
dc.date.issued2016
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/4094-
dc.description.abstractRadiopharmaceuticals are a convenient tool in nuclear medicine for diagnosis and treatment of different pathologies. Their application is of great interest in oncology and infectious diseases therefore investigations on the development of nanoparticles for such purposes are under focus. Their characteristics need to be studied before application as many therapeutic drugs suffer from a poor balance between efficacy and toxicity. Nuclear medicine imaging techniques such as PET are being valuable (pre)clinical tools to non‐invasively assess drug performance in pharmaceutical research providing understanding into structure-property relationships in vivo towards optimization to more effective drug delivery. In this study, different metal radioisotopes have been conjugated to diverse biomolecules such as antibodies, small based peptides molecules or polymer based micelles in order investigate their efficiency as disease imaging targets. Hence, versatile radiolabelling strategies were developed according to the requirements of each biomolecule and subsequent evaluations in vitro and in vivo were performed.en_GB
dc.language.isoeng
dc.rightsin Copyrightde_DE
dc.rights.urihttps://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleRadiolabelling, "in vitro" and "in vivo" evaluation of metal-labelled biomolecules for PET imagingen_GB
dc.typeDissertationde_DE
dc.identifier.urnurn:nbn:de:hebis:77-diss-1000005854
dc.identifier.doihttp://doi.org/10.25358/openscience-4092-
jgu.type.dinitypedoctoralThesis
jgu.type.versionOriginal worken_GB
jgu.type.resourceText
jgu.description.extent161 Seiten
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.-
jgu.organisation.year2016
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.organisation.placeMainz-
jgu.subject.ddccode540
opus.date.accessioned2016-07-25T12:04:18Z
opus.date.modified2016-08-09T11:01:02Z
opus.date.available2016-07-25T14:04:18
opus.subject.dfgcode00-000
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Kernchemiede_DE
opus.identifier.opusid100000585
opus.institute.number0904
opus.metadataonlyfalse
opus.type.contenttypeDissertationde_DE
opus.type.contenttypeDissertationen_GB
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