Authors:	Schilmann, Anna-Maria
Title:	Synthese und Biofunktionalisierung von SiO2-Nanopartikeln zur Anwendung in der Krebsimmuntherapie
Online publication date:	15-Mar-2017
Year of first publication:	2017
Language:	german
Abstract:	In the field of cancer immunotherapy more and more nanoparticle systems are being used. In addition to chemotherapy and irradiation, they are meant to assist/support surgery. The re-placement of both systemic therapies by a local application/therapy would be desirable. By equipping the nanoparticles with specific target vectors for cells, such a local therapy could be realized. Furthermore, the particles can be used as carriers for pharmaceuticals or as "infor-mation carriers" to aid the immune system in fighting disease. Using metal or metal oxide nanoparticles also provides a contrast agent for imaging such as MRI/CT. Other particles can be functionalized with imaging ligands for applications in PET, for example. Silica and silica-based nanoparticles are of high interest due to their low toxicity, good solubility, high biocompatibility and good modifiability. They can easily be combined with other materials to increase their versatility. Silica can occur in different morphologies and structures (mesoporous), allowing a wide range of applications. Using a silane anchor, functional ligands can be covalently bound to the surface of the particles, which leads to a stable system for biomedical applications. The focus of this work was thus to synthesize and modify different silica and silica-based nanoparticles for various applications, such as cancer immunotherapy and cancer treatment. Studies mainly explored how the varying cells of the immune system reacted to the nano-particle treatment. Further investigations addressed whether it is possible to bind complex structures, such as proteins, to the particle surface without losing bioactivity, as well as if particles bound to tumor cells could be used as contrast agents.
DDC:	500 Naturwissenschaften 500 Natural sciences and mathematics
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-3310
URN:	urn:nbn:de:hebis:77-diss-1000010880
Version:	Original work
Publication type:	Dissertation
License:	In Copyright
Information on rights of use:	https://rightsstatements.org/vocab/InC/1.0/
Extent:	vi, 172, LI Seiten
Appears in collections:	JGU-Publikationen