Authors:	Thomi, Laura
Title:	Functional nanocarriers as compartments for artificial cells
Online publication date:	27-Jan-2018
Year of first publication:	2018
Language:	english
Abstract:	This work presents an exploratory study towards a functional compartment usable for bottom up approach of a minimal cell. Two projects deal with permeable nanocontainers, either redoxresponsive nanocapsules or permeable polymersomes. The two remaining projects deal with functional nanocontainers, i.e. polymersomes with different surface functionalisations and polymersomes from biodegradable poly(phosphoesters). In conclusion, different nanocarriers bearing either chemical functionalities or responsiveness were developed. In synthetic biology, such containers are needed to separate and protect their cargo and mimic certain cell functions. The functionality introduces a communication path to the outside, e.g. through redox-responsiveness or adhesion. Functional nanocarriers serve as a platform to develop interacting systems of increasing complexity until at some point, those complex systems resemble a minimal cell.
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-2840
URN:	urn:nbn:de:hebis:77-diss-1000018627
Version:	Original work
Publication type:	Dissertation
License:	In Copyright
Information on rights of use:	https://rightsstatements.org/vocab/InC/1.0/
Extent:	133 Seiten
Appears in collections:	JGU-Publikationen