Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-273Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Baranowski, Andreas | - |
| dc.contributor.author | Klein, Anja | - |
| dc.contributor.author | Ritz, Ulrike | - |
| dc.contributor.author | Götz, Hermann | - |
| dc.contributor.author | Mattyasovszky, Stefan | - |
| dc.contributor.author | Rommens, Pol Maria | - |
| dc.contributor.author | Hofmann, Alexander | - |
| dc.date.accessioned | 2019-01-08T15:18:52Z | - |
| dc.date.available | 2019-01-08T16:18:52Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/275 | - |
| dc.description.abstract | The bioactive coating of calcium phosphate cement (CPC) is a promising approach to enhance the bone-healing properties of bone substitutes. The purpose of this study was to evaluate whether coating CPCs with bone sialoprotein (BSP) results in increased bone formation. Forty-five female C57BL/6NRj mice with an average age of six weeks were divided into three groups. Either a BSP-coated or an uncoated three-dimensional plotted scaffold was implanted into a drilled 2.7-mm diameter calvarial defect, or the defect was left empty (control group; no CPC). Histological analyses revealed that BSP-coated scaffolds were better integrated into the local bone stock eight weeks after implantation. Bone volume/total volume (BV/TV) ratios and bone thickness at the bone-implant contact were analyzed via micro computed tomography (µCT) after eight weeks. BSP-coated scaffolds and uncoated CPC scaffolds increased bone thickness in comparison to the control (CPC + BSP: 691.1 ± 253.5 µm, CPC: 603.1 ± 164.4 µm, no CPC: 261.7 ± 37.8 µm, p < 0.01). Accordingly, BV/TV was enhanced in both scaffold groups (CPC + BSP: 1.3 ± 0.5%, CPC: 0.9 ± 0.5%, no CPC: 0.2 ± 0.3%, p < 0.01). The BSP coating showed a tendency towards an increased bone thickness (p = 0.18) and BV/TV (p = 0.18) in comparison to uncoated CPC scaffolds. However, a significant increase in bone formation through BSP coating was not found. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | - |
| dc.language.iso | eng | - |
| dc.rights | CC BY | de_DE |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Evaluation of bone sialoprotein coating of three-dimensional printed calcium phosphate scaffolds in a calvarial defect model in mice | en_GB |
| dc.type | Zeitschriftenaufsatz | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-publ-587623 | - |
| dc.identifier.doi | http://doi.org/10.25358/openscience-273 | - |
| jgu.type.dinitype | article | - |
| jgu.type.version | Published version | en_GB |
| jgu.type.resource | Text | - |
| jgu.organisation.department | FB 04 Medizin | - |
| jgu.organisation.department | FB 02 Sozialwiss., Medien u. Sport | - |
| jgu.organisation.number | 7910 | - |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Materials | - |
| jgu.journal.volume | 11 | - |
| jgu.journal.issue | 11 | - |
| jgu.pages.alternative | Art. 2336 | - |
| jgu.publisher.year | 2018 | - |
| jgu.publisher.name | MDPI | - |
| jgu.publisher.place | Basel | - |
| jgu.publisher.uri | http://dx.doi.org/10.3390/ma11112336 | - |
| jgu.publisher.issn | 1996-1944 | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | - |
| opus.date.accessioned | 2019-01-08T15:18:52Z | - |
| opus.date.modified | 2019-01-22T09:10:42Z | - |
| opus.date.available | 2019-01-08T16:18:52 | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 02: Sozialwissenschaften, Medien und Sport: Psychologisches Institut | de_DE |
| opus.organisation.string | FB 04: Medizin: Klinik und Poliklinik für Unfallchirurgie | de_DE |
| opus.identifier.opusid | 58762 | - |
| opus.institute.number | 0204 | - |
| opus.institute.number | 0439 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_GB |
| opus.affiliated | Baranowski, Andreas | - |
| opus.affiliated | Klein, Anja | - |
| opus.affiliated | Ritz, Ulrike | - |
| opus.affiliated | Mattyasovszky, Stefan | - |
| opus.affiliated | Rommens, Pol Maria | - |
| jgu.publisher.doi | 10.3390/ma11112336 | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
