Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-273
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dc.contributor.authorBaranowski, Andreas-
dc.contributor.authorKlein, Anja-
dc.contributor.authorRitz, Ulrike-
dc.contributor.authorGötz, Hermann-
dc.contributor.authorMattyasovszky, Stefan-
dc.contributor.authorRommens, Pol Maria-
dc.contributor.authorHofmann, Alexander-
dc.date.accessioned2019-01-08T15:18:52Z-
dc.date.available2019-01-08T16:18:52Z-
dc.date.issued2018-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/275-
dc.description.abstractThe bioactive coating of calcium phosphate cement (CPC) is a promising approach to enhance the bone-healing properties of bone substitutes. The purpose of this study was to evaluate whether coating CPCs with bone sialoprotein (BSP) results in increased bone formation. Forty-five female C57BL/6NRj mice with an average age of six weeks were divided into three groups. Either a BSP-coated or an uncoated three-dimensional plotted scaffold was implanted into a drilled 2.7-mm diameter calvarial defect, or the defect was left empty (control group; no CPC). Histological analyses revealed that BSP-coated scaffolds were better integrated into the local bone stock eight weeks after implantation. Bone volume/total volume (BV/TV) ratios and bone thickness at the bone-implant contact were analyzed via micro computed tomography (µCT) after eight weeks. BSP-coated scaffolds and uncoated CPC scaffolds increased bone thickness in comparison to the control (CPC + BSP: 691.1 ± 253.5 µm, CPC: 603.1 ± 164.4 µm, no CPC: 261.7 ± 37.8 µm, p < 0.01). Accordingly, BV/TV was enhanced in both scaffold groups (CPC + BSP: 1.3 ± 0.5%, CPC: 0.9 ± 0.5%, no CPC: 0.2 ± 0.3%, p < 0.01). The BSP coating showed a tendency towards an increased bone thickness (p = 0.18) and BV/TV (p = 0.18) in comparison to uncoated CPC scaffolds. However, a significant increase in bone formation through BSP coating was not found.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleEvaluation of bone sialoprotein coating of three-dimensional printed calcium phosphate scaffolds in a calvarial defect model in miceen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.urnurn:nbn:de:hebis:77-publ-587623-
dc.identifier.doihttp://doi.org/10.25358/openscience-273-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 04 Medizin-
jgu.organisation.departmentFB 02 Sozialwiss., Medien u. Sport-
jgu.organisation.number7910-
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleMaterials-
jgu.journal.volume11-
jgu.journal.issue11-
jgu.pages.alternativeArt. 2336-
jgu.publisher.year2018-
jgu.publisher.nameMDPI-
jgu.publisher.placeBasel-
jgu.publisher.urihttp://dx.doi.org/10.3390/ma11112336-
jgu.publisher.issn1996-1944-
jgu.organisation.placeMainz-
jgu.subject.ddccode610-
opus.date.accessioned2019-01-08T15:18:52Z-
opus.date.modified2019-01-22T09:10:42Z-
opus.date.available2019-01-08T16:18:52-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 02: Sozialwissenschaften, Medien und Sport: Psychologisches Institutde_DE
opus.organisation.stringFB 04: Medizin: Klinik und Poliklinik für Unfallchirurgiede_DE
opus.identifier.opusid58762-
opus.institute.number0204-
opus.institute.number0439-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedBaranowski, Andreas-
opus.affiliatedKlein, Anja-
opus.affiliatedRitz, Ulrike-
opus.affiliatedMattyasovszky, Stefan-
opus.affiliatedRommens, Pol Maria-
jgu.publisher.doi10.3390/ma11112336
Appears in collections:JGU-Publikationen

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