Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-254Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Khandagale, Avinash | - |
| dc.contributor.author | Kittner, Jens M. | - |
| dc.contributor.author | Mann, Amrit | - |
| dc.contributor.author | Ascher, Stefanie | - |
| dc.contributor.author | Kollar, Bettina | - |
| dc.contributor.author | Reinhardt, Christoph | - |
| dc.date.accessioned | 2018-12-19T12:48:47Z | - |
| dc.date.available | 2018-12-19T13:48:47Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/256 | - |
| dc.description.abstract | Patients with inflammatory bowel disease (IBD) are susceptible to thromboembolism. Interestingly, IBD occurs less frequently in patients with inherited bleeding disorders. Therefore, we analyzed whether F9-deficiency is protective against the onset of acute colitis in a genetic hemophilia B mouse model. In the 3.5% dextran sulfate sodium (DSS)-induced colitis model, F9 deficient mice were protected from body-weight loss and had a reduced disease activity score. We detected decreased colonic myeloperoxidase activity and decreased CXCL1 levels in DSS-treated F9 deficient mice compared with wild-type (WT) littermate controls, indicating decreased neutrophil infiltration. Remarkably, we identified expression of coagulation factor IX (FIX) protein in small intestinal epithelial cells (MODE-K). In epithelial cell cultures, cellular FIX protein expression was increased following stimulation with the bacterial Toll-like receptor agonists lipopolysaccharide, macrophage-activating lipopeptide-2 and Pam3CSK4. Thus, we revealed a protective role of F9-deficiency in DSS-induced colitis and identified the intestinal epithelium as a site of ectopic FIX.This article has an associated First Person interview with the first author of the paper. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | - |
| dc.language.iso | eng | - |
| dc.rights | CC BY | de_DE |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | - |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis | en_GB |
| dc.type | Zeitschriftenaufsatz | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-publ-587104 | - |
| dc.identifier.doi | http://doi.org/10.25358/openscience-254 | - |
| jgu.type.dinitype | article | - |
| jgu.type.version | Published version | en_GB |
| jgu.type.resource | Text | - |
| jgu.organisation.department | FB 04 Medizin | - |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Biology open | - |
| jgu.journal.volume | 7 | - |
| jgu.journal.issue | 7 | - |
| jgu.pages.alternative | bio034140 | - |
| jgu.publisher.year | 2018 | - |
| jgu.publisher.name | Company | - |
| jgu.publisher.place | Cambridge | - |
| jgu.publisher.uri | http://dx.doi.org/10.1242/bio.034140 | - |
| jgu.publisher.issn | 2046-6390 | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | - |
| opus.date.accessioned | 2018-12-19T12:48:47Z | - |
| opus.date.modified | 2019-01-10T11:01:33Z | - |
| opus.date.available | 2018-12-19T13:48:47 | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 04: Medizin: Centrum für Thrombose und Hämostase (CTH) | de_DE |
| opus.organisation.string | FB 04: Medizin: I. Medizinische Klinik und Poliklinik | de_DE |
| opus.identifier.opusid | 58710 | - |
| opus.institute.number | 0463 | - |
| opus.institute.number | 0425 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_GB |
| opus.affiliated | Kittner, Jens M. | - |
| opus.affiliated | Reinhardt, Christoph | - |
| jgu.publisher.doi | 10.1242/bio.034140 | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
