Autoren:	Ritter, Katharina Somnuke, Pawit Hu, Lingjiao Griemert, Eva-Verena Schäfer, Michael K.E.
Titel:	Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models
Online-Publikationsdatum:	15-Mär-2024
Erscheinungsdatum:	2024
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgical site infections or meningitis are frequent complications following TBI. Whether the use of preventive and/or symptomatic antibiotic therapy improves patient mortality and outcome is an ongoing matter of debate. In contrast, results from animal models of TBI suggest translational perspectives and support the hypothesis that antibiotics, independent of their anti-microbial activity, alleviate secondary injury and improve neurological outcomes. These beneficial effects were largely attributed to the inhibition of neuroinflammation and neuronal cell death. In this review, we briefly outline current treatment options, including antibiotic therapy, for patients with TBI. We then summarize the therapeutic effects of the most commonly tested antibiotics in TBI animal models, highlight studies identifying molecular targets of antibiotics, and discuss similarities and differences in their mechanistic modes of action.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10221
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Review
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	BMC neuroscience 25
Seitenzahl oder Artikelnummer:	10
Verlag:	BioMed Central
Verlagsort:	London
Erscheinungsdatum:	2024
ISSN:	1471-2202
DOI der Originalveröffentlichung:	10.1186/s12868-024-00851-6
Enthalten in den Sammlungen:	DFG-491381577-G