Gutenberg Open Science: Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-10221

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DC Field	Value	Language
dc.contributor.author	Ritter, Katharina	-
dc.contributor.author	Somnuke, Pawit	-
dc.contributor.author	Hu, Lingjiao	-
dc.contributor.author	Griemert, Eva-Verena	-
dc.contributor.author	Schäfer, Michael K.E.	-
dc.date.accessioned	2024-03-15T07:35:29Z	-
dc.date.available	2024-03-15T07:35:29Z	-
dc.date.issued	2024	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/10239	-
dc.description.abstract	TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgical site infections or meningitis are frequent complications following TBI. Whether the use of preventive and/or symptomatic antibiotic therapy improves patient mortality and outcome is an ongoing matter of debate. In contrast, results from animal models of TBI suggest translational perspectives and support the hypothesis that antibiotics, independent of their anti-microbial activity, alleviate secondary injury and improve neurological outcomes. These beneficial effects were largely attributed to the inhibition of neuroinflammation and neuronal cell death. In this review, we briefly outline current treatment options, including antibiotic therapy, for patients with TBI. We then summarize the therapeutic effects of the most commonly tested antibiotics in TBI animal models, highlight studies identifying molecular targets of antibiotics, and discuss similarities and differences in their mechanistic modes of action.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-10221	-
jgu.type.contenttype	Review	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	BMC neuroscience	de
jgu.journal.volume	25	de
jgu.pages.alternative	10	de
jgu.publisher.year	2024	-
jgu.publisher.name	BioMed Central	de
jgu.publisher.place	London	de
jgu.publisher.issn	1471-2202	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1186/s12868-024-00851-6	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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