Autoren:	Mirzac, Daniela Kreis, Svenja L. Luhmann, Heiko J. Gonzalez-Escamilla, Gabriel Groppa, Sergiu
Titel:	Translating pathological brain activity primers in Parkinson’s disease research
Online-Publikationsdatum:	16-Feb-2024
Erscheinungsdatum:	2023
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Translational experimental approaches that help us better trace Parkinson’s disease (PD) pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In this article, we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations, as well as their underlying mechanisms and modulation. Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation. Here, we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits. We summarize recent achievements extrapolated from available PD animal models, discuss their advantages and limitations, debate on their differential applicability, and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10023
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Research 6
Seitenzahl oder Artikelnummer:	0183
Verlag:	China Association for Science and Technology
Verlagsort:	Beijing
Erscheinungsdatum:	2023
ISSN:	2639-5274
DOI der Originalveröffentlichung:	10.34133/research.0183
Enthalten in den Sammlungen:	DFG-491381577-G