Gutenberg Open Science: Translating pathological brain activity primers in Parkinson’s disease research

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-10023

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DC Field	Value	Language
dc.contributor.author	Mirzac, Daniela	-
dc.contributor.author	Kreis, Svenja L.	-
dc.contributor.author	Luhmann, Heiko J.	-
dc.contributor.author	Gonzalez-Escamilla, Gabriel	-
dc.contributor.author	Groppa, Sergiu	-
dc.date.accessioned	2024-02-16T09:49:52Z	-
dc.date.available	2024-02-16T09:49:52Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/10041	-
dc.description.abstract	Translational experimental approaches that help us better trace Parkinson’s disease (PD) pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In this article, we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations, as well as their underlying mechanisms and modulation. Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation. Here, we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits. We summarize recent achievements extrapolated from available PD animal models, discuss their advantages and limitations, debate on their differential applicability, and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Translating pathological brain activity primers in Parkinson’s disease research	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-10023	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Research	de
jgu.journal.volume	6	de
jgu.pages.alternative	0183	de
jgu.publisher.year	2023	-
jgu.publisher.name	China Association for Science and Technology	de
jgu.publisher.place	Beijing	de
jgu.publisher.issn	2639-5274	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.34133/research.0183	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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