Autoren:	Ernst, Mareike Hinz, Andreas Brähler, Elmar Merzenich, Hiltrud Faber, Jörg Wild, Philipp S. Beutel, Manfred E.
Titel:	Quality of life after pediatric cancer : comparison of long-term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators
Online-Publikationsdatum:	15-Feb-2024
Erscheinungsdatum:	2023
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Background This study aimed to compare the quality of life (QoL) reported by childhood cancer survivors (CCS) drawn from a cohort of the German Childhood Cancer Registry with a representative general population sample and, within CCS, to test associations between QoL and health behavior, health risk factors, and physical illness. Methods CCS (N=633, age at diagnosis M=6.34 (SD=4.38), age at medical assessment M=34.92 (SD=5.70)) and a general population sample (age-aligned; N=975) flled out the EORTC QLQ-C30. Comparisons were performed using General linear models (GLMs) (fxed efects: sex/gender, group (CCS vs. general population); covariates: age, educa tion level). CCS underwent an extensive medical assessment (mean time from diagnosis to assessment was 28.07 (SD=3.21) years) including an objective diagnosis of health risk factors and physical illnesses (e.g., diabetes and car diovascular disease). Within CCS, we tested associations between QoL and sociodemographic characteristics, health behavior, health risk factors, and physical illness. Results CCS, especially female CCS, reported both worse functional QoL and higher symptom burden than the general population. Among CCS, better total QoL was related to younger age, higher level of education, being mar ried, and engaging in active sports. Both health risk factors (dyslipidemia and physical inactivity) and manifest physical illnesses (cardiovascular disease) were associated with lower total QoL. Conclusions In all domains, long-term CCS reported worse QoL than the comparison sample. The negative associa tions with risk factors and physical illnesses indicate an urgent need for long-term surveillance and health promotion.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10018
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Health and quality of life outcomes 21
Seitenzahl oder Artikelnummer:	65
Verlag:	BioMed Central
Verlagsort:	London
Erscheinungsdatum:	2023
ISSN:	1477-7525
DOI der Originalveröffentlichung:	10.1186/s12955-023-02153-7
Enthalten in den Sammlungen:	DFG-491381577-G