Gutenberg Open Science: Quality of life after pediatric cancer : comparison of long-term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-10018

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DC Field	Value	Language
dc.contributor.author	Ernst, Mareike	-
dc.contributor.author	Hinz, Andreas	-
dc.contributor.author	Brähler, Elmar	-
dc.contributor.author	Merzenich, Hiltrud	-
dc.contributor.author	Faber, Jörg	-
dc.contributor.author	Wild, Philipp S.	-
dc.contributor.author	Beutel, Manfred E.	-
dc.date.accessioned	2024-02-15T09:40:04Z	-
dc.date.available	2024-02-15T09:40:04Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/10036	-
dc.description.abstract	Background This study aimed to compare the quality of life (QoL) reported by childhood cancer survivors (CCS) drawn from a cohort of the German Childhood Cancer Registry with a representative general population sample and, within CCS, to test associations between QoL and health behavior, health risk factors, and physical illness. Methods CCS (N=633, age at diagnosis M=6.34 (SD=4.38), age at medical assessment M=34.92 (SD=5.70)) and a general population sample (age-aligned; N=975) flled out the EORTC QLQ-C30. Comparisons were performed using General linear models (GLMs) (fxed efects: sex/gender, group (CCS vs. general population); covariates: age, educa tion level). CCS underwent an extensive medical assessment (mean time from diagnosis to assessment was 28.07 (SD=3.21) years) including an objective diagnosis of health risk factors and physical illnesses (e.g., diabetes and car diovascular disease). Within CCS, we tested associations between QoL and sociodemographic characteristics, health behavior, health risk factors, and physical illness. Results CCS, especially female CCS, reported both worse functional QoL and higher symptom burden than the general population. Among CCS, better total QoL was related to younger age, higher level of education, being mar ried, and engaging in active sports. Both health risk factors (dyslipidemia and physical inactivity) and manifest physical illnesses (cardiovascular disease) were associated with lower total QoL. Conclusions In all domains, long-term CCS reported worse QoL than the comparison sample. The negative associa tions with risk factors and physical illnesses indicate an urgent need for long-term surveillance and health promotion.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Quality of life after pediatric cancer : comparison of long-term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-10018	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Health and quality of life outcomes	de
jgu.journal.volume	21	de
jgu.pages.alternative	65	de
jgu.publisher.year	2023	-
jgu.publisher.name	BioMed Central	de
jgu.publisher.place	London	de
jgu.publisher.issn	1477-7525	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1186/s12955-023-02153-7	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-491381577-G

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