Complaints of sleep disturbances are associated with cardiovascular disease : results from the Gutenberg Health Study

dc.contributor.authorMichal, Matthias
dc.contributor.authorWiltink, Jörg
dc.contributor.authorKirschner, Yvonne
dc.contributor.authorSchneider, Astrid
dc.contributor.authorWild, Philipp
dc.contributor.authorMünzel, Thomas
dc.contributor.authorBlettner, Maria
dc.contributor.authorSchulz, Andreas
dc.contributor.authorLackner, Karl J.
dc.contributor.authorPfeiffer, Norbert
dc.contributor.authorBlankenberg, Stefan
dc.contributor.authorTschan, Regine
dc.contributor.authorTuin, Inka
dc.contributor.authorBeutel, Manfred E.
dc.date.accessioned2022-07-11T09:58:27Z
dc.date.available2022-07-11T09:58:27Z
dc.date.issued2014
dc.description.abstractBACKGROUND: Despite their high prevalence, sleep disorders often remain unrecognized and untreated because of barriers to assessment and management. The aims of the present study were to examine associations of complaints of sleep disturbances with cardiovascular disease, related risk factors, and inflammation in the community and to determine the contribution of sleep disturbances to self-perceived physical health. METHOD: The sample consists of n = 10.000 participants, aged 35 to 74 years of a population based community sample in Germany. Cross-sectional associations of complaints of sleep disturbances with cardiovascular risk factors and disease, biomarkers of inflammation, depression, anxiety, and physical health status were analyzed. RESULTS: 19% of our sample endorsed clinically significant sleep disturbances. In the unadjusted analyses severity of sleep disturbances increased with female sex, low socioeconomic status, living without a partnership, cardiovascular disease, depression, anxiety, poor physical health, increased levels of C-reactive protein and fibrinogen. After multivariate adjustment robust associations with coronary heart disease, myocardial infarction and dyslipidemia remained. Complaints of sleep disturbances were strong and independent contributors to self-perceived poor physical health beyond depression, anxiety and medical disease burden. CONCLUSIONS: Given the high prevalence of complaints of sleep disturbances and their strong impact on health status, increased efforts should be undertaken for their identification and treatment.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.identifier.doihttp://doi.org/10.25358/openscience-7344
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7358
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleComplaints of sleep disturbances are associated with cardiovascular disease : results from the Gutenberg Health Studyen_GB
dc.typeZeitschriftenaufsatzde
jgu.identifier.pmid25093413
jgu.journal.issue8de
jgu.journal.titlePLoS onede
jgu.journal.volume9de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternativee104324de
jgu.publisher.doi10.1371/journal.pone.0104324de
jgu.publisher.issn1932-6203de
jgu.publisher.namePLoSde
jgu.publisher.placeLawrence, Kan.de
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0104324de
jgu.publisher.year2014
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde
opus.affiliatedMichal, Matthias
opus.affiliatedWiltink, Jörg
opus.affiliatedSchneider, Astrid
opus.affiliatedWild, Philipp
opus.affiliatedMünzel, Thomas
opus.affiliatedBlettner, Maria
opus.affiliatedLackner, Karl J.
opus.affiliatedPfeiffer, Norbert
opus.affiliatedTschan, Regine
opus.affiliatedTuin, Inka
opus.affiliatedBeutel, Manfred E.
opus.date.modified2018-08-08T09:19:16Z
opus.identifier.opusid27392
opus.importsourcepubmed
opus.institute.number0424
opus.institute.number0426
opus.institute.number0428
opus.institute.number0434
opus.institute.number0446
opus.metadataonlyfalse
opus.organisation.stringFB 04: Medizin: Institut für Med. Biometrie, Epidemologie und Informatikde_DE
opus.organisation.stringFB 04: Medizin: II. Medizinische Klinik und Poliklinikde_DE
opus.organisation.stringFB 04: Medizin: Institut für Klinische Chemie und Laboratoriumsmedizinde_DE
opus.organisation.stringFB 04: Medizin: Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapiede_DE
opus.organisation.stringFB 04: Medizin: Augenklinik und Poliklinikde_DE
opus.subject.dfgcode00-000
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN

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