Direct electrochemical synthesis of 2,3-disubstituted quinoline N-oxides by cathodic reduction of nitro arenes
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Abstract
The use of electric current in synthetic organic chemistry offers a sustainable tool for the selective reductive synthesis of quinoline N-oxides starting from easily accessible nitro compounds. The reported method employs mild and reagent-free conditions, a simple undivided cell, and constant current electrolysis set-up which provides conversion with a high atom economy. The synthesis of 30 differently substituted quinoline N-oxides was successfully performed in up to 90 % yield. Using CV studies, the mechanism of the selective formation of the quinoline N-oxides was elucidated. The technical relevance of the described reaction could be shown in a 50-fold scale-up reaction.
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Chemistry - a European journal, 29, 12, Wiley, Weinheim, 2022, https://doi.org/10.1002/chem.202203319