Bi-Gaussian analysis reveals distinct education-related alterations in spherical equivalent and axial length : results from the Gutenberg Health Study

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dc.contributor.authorHartmann, Alica
dc.contributor.authorGrabitz, Stephanie Desirée
dc.contributor.authorWagner, Felix Mathias
dc.contributor.authorWild, Philipp Sebastian
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorLackner, Karl Johannes
dc.contributor.authorBeutel, Manfred Elmar
dc.contributor.authorMünzel, Thomas
dc.contributor.authorTüscher, Oliver
dc.contributor.authorSchattenberg, Jörn Markus
dc.contributor.authorPfeiffer, Norbert
dc.contributor.authorSchuster, Alexander Karl-Georg
dc.date.accessioned2025-08-21T07:44:39Z
dc.date.available2025-08-21T07:44:39Z
dc.date.issued2024
dc.description.abstractPurpose: The aim of this study is to investigate the distribution of spherical equivalent and axial length in the general population and to analyze the influence of education on spherical equivalent with a focus on ocular biometric parameters. Methods: The Gutenberg Health Study is a population-based cohort study in Mainz, Germany. Participants underwent comprehensive ophthalmologic examinations as part of the 5-year follow-up examination in 2012–2017 including genotyping. The spherical equivalent and axial length distributions were modeled with gaussian mixture models. Regression analysis (on person-individual level) was performed to analyze associations between biometric parameters and educational factors. Mendelian randomization analysis explored the causal effect between spherical equivalent, axial length, and education. Additionally, effect mediation analysis examined the link between spherical equivalent and education. Results: A total of 8532 study participants were included (median age: 57 years, 49%en
dc.identifier.doihttps://doi.org/10.25358/openscience-11285
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/11306
dc.language.isoengde
dc.rightsCC-BY-4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610 Medizinde
dc.subject.ddc610 Medical sciencesen
dc.titleBi-Gaussian analysis reveals distinct education-related alterations in spherical equivalent and axial length : results from the Gutenberg Health Studyen
dc.typeZeitschriftenaufsatzde
jgu.journal.titleGraefe's archive for clinical and experimental ophthalmologyde
jgu.journal.volume262de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end1828de
jgu.pages.start1819de
jgu.publisher.doi10.1007/s00417-024-06395-zde
jgu.publisher.issn1435-702Xde
jgu.publisher.nameSpringerde
jgu.publisher.placeBerlin, Heidelbergde
jgu.publisher.year2024
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.subject.dfgLebenswissenschaftende
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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