Cytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluation

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dc.contributor.authorSchirmeister, Tanja
dc.contributor.authorOli, Swarna
dc.contributor.authorWu, Hongmei
dc.contributor.authorDella Sala, Gerardo
dc.contributor.authorCostantino, Valeria
dc.contributor.authorSeo, Ean-Jeong
dc.contributor.authorEfferth, Thomas
dc.date.accessioned2022-10-21T07:32:14Z
dc.date.available2022-10-21T07:32:14Z
dc.date.issued2017
dc.description.abstractThe 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (5), as well as the esters plakortide E methyl ester (6) and 6-epi-plakortide H (7) were synthesized by hydrolysis and Steglich esterification, respectively. The data obtained showed that the acids (1, 2, 5) exhibited potent cytotoxicity towards both cell lines, whereas the esters showed no activity (6, 7) or weaker activity (3, 4) compared to their corresponding acids. Plakortic acid (5) was the most promising derivative with half maximal inhibitory concentration (IC50) values of ca. 0.20 µM for both cell lines.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.identifier.doihttp://doi.org/10.25358/openscience-8142
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8157
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleCytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluationen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.issue3de
jgu.journal.titleMarine drugsde
jgu.journal.volume15de
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.de
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number7950
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternativeArt. 63de
jgu.publisher.doi10.3390/md15030063de
jgu.publisher.issn1660-3397de
jgu.publisher.nameMolecular Diversity Preservation Internationalde
jgu.publisher.placeBaselde
jgu.publisher.urihttp://dx.doi.org/10.3390/md15030063de
jgu.publisher.year2017
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode570de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde
opus.affiliatedSchirmeister, Tanja
opus.affiliatedOli, Swarna
opus.affiliatedWu, Hongmei
opus.affiliatedEfferth, Thomas
opus.date.modified2017-06-13T08:11:59Z
opus.identifier.opusid56758
opus.institute.number0908
opus.metadataonlyfalse
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Pharmaziede_DE
opus.subject.dfgcode00-000
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN

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