Cytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluation

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dc.contributor.authorSchirmeister, Tanja
dc.contributor.authorOli, Swarna
dc.contributor.authorWu, Hongmei
dc.contributor.authorDella Sala, Gerardo
dc.contributor.authorCostantino, Valeria
dc.contributor.authorSeo, Ean-Jeong
dc.contributor.authorEfferth, Thomas
dc.date.accessioned2022-10-21T07:32:14Z
dc.date.available2022-10-21T07:32:14Z
dc.date.issued2017
dc.description.abstractThe 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (5), as well as the esters plakortide E methyl ester (6) and 6-epi-plakortide H (7) were synthesized by hydrolysis and Steglich esterification, respectively. The data obtained showed that the acids (1, 2, 5) exhibited potent cytotoxicity towards both cell lines, whereas the esters showed no activity (6, 7) or weaker activity (3, 4) compared to their corresponding acids. Plakortic acid (5) was the most promising derivative with half maximal inhibitory concentration (IC50) values of ca. 0.20 µM for both cell lines.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
dc.identifier.doihttp://doi.org/10.25358/openscience-8142
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8157
dc.language.isoeng
dc.rightsCC-BY-4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleCytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluationen_GB
dc.typeZeitschriftenaufsatzde_DE
jgu.apc.price1812,37
jgu.journal.issue3
jgu.journal.titleMarine drugs
jgu.journal.volume15
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.de_DE
jgu.organisation.nameJohannes Gutenberg-Universität Mainzde_DE
jgu.organisation.number7950
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternativeArt. 63
jgu.publisher.doi10.3390/md15030063
jgu.publisher.issn1660-3397
jgu.publisher.nameMolecular Diversity Preservation International
jgu.publisher.placeBasel
jgu.publisher.urihttp://dx.doi.org/10.3390/md15030063
jgu.publisher.year2017
jgu.rights.accessrightsopenAccessen_GB
jgu.subject.ddccode570
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTexten_GB
jgu.type.versionPublished versionen_GB
opus.affiliatedSchirmeister, Tanja
opus.affiliatedOli, Swarna
opus.affiliatedWu, Hongmei
opus.affiliatedEfferth, Thomas
opus.date.modified2017-06-13T08:11:59Z
opus.identifier.opusid56758
opus.institute.number0908
opus.metadataonlyfalse
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Pharmazie
opus.subject.dfgcode00-000
opus.type.contenttypeKeine
opus.type.contenttypeNone

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