Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin

Schröger, Saskia-Vanessa; Blatt, Sebastian; Sagheb, Kawe; Al-Nawas, Bilal; Kämmerer, Peer W.; Sagheb, Keyvan

doi:https://doi.org/10.25358/openscience-10984

Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin

dc.contributor.author	Schröger, Saskia-Vanessa
dc.contributor.author	Blatt, Sebastian
dc.contributor.author	Sagheb, Kawe
dc.contributor.author	Al-Nawas, Bilal
dc.contributor.author	Kämmerer, Peer W.
dc.contributor.author	Sagheb, Keyvan
dc.date.accessioned	2025-08-20T13:20:52Z
dc.date.available	2025-08-20T13:20:52Z
dc.date.issued	2024
dc.description.abstract	Objectives: Pre-vascularization of the collagen membranes with autologous platelet concentrates is a standard procedure in oral and maxillofacial surgery. This study analyzed the possible interaction of an acellular collagen membrane of porcine origin (NM) with platelet-rich fibrin (PRF) regarding its rehydration protocol with differences in pH values and effect on angiogenesis. Materials and methods: NM was analyzed alone and combined with solid PRF by plotting or co-culturing with injectable PRF. Different media (venous blood, buffer solution with a fixed pH value of 7, saline solution, and injectable PRF) were used to analyze the influence on pH value during rehydration. Chorion allantois membrane assay (CAM) was applied to check pro-angiogenic effects after 24, 48, and 72 h, followed by immunohistochemical analysis. Results: Rehydration in injectable PRF showed acidity over time (p < 0.05). A definite pro-angiogenic effect of NM alone was found regarding neo-vessel formation supported by the respective li	en
dc.identifier.doi	https://doi.org/10.25358/openscience-10984
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/11003
dc.language.iso	eng	de
dc.rights	CC-BY-4.0
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610 Medizin	de
dc.subject.ddc	610 Medical sciences	en
dc.title	Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin	en
dc.type	Zeitschriftenaufsatz	de
jgu.journal.title	Clinical oral investigations	de
jgu.journal.volume	28	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.name	Johannes Gutenberg-Universität Mainz
jgu.organisation.number	2700
jgu.organisation.place	Mainz
jgu.organisation.ror	https://ror.org/023b0x485
jgu.pages.alternative	99	de
jgu.publisher.doi	10.1007/s00784-023-05485-2	de
jgu.publisher.issn	1436-3771	de
jgu.publisher.name	Springer	de
jgu.publisher.place	Berlin, Heidelberg	de
jgu.publisher.year	2024
jgu.rights.accessrights	openAccess
jgu.subject.ddccode	610	de
jgu.subject.dfg	Lebenswissenschaften	de
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	Article	en_GB
jgu.type.resource	Text	de
jgu.type.version	Published version	de

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