Dissipative organization of DNA oligomers for transient catalytic function
dc.contributor.author | Deng, Jie | |
dc.contributor.author | Liu, Wei | |
dc.contributor.author | Sun, Mo | |
dc.contributor.author | Walther, Andreas | |
dc.date.accessioned | 2023-02-03T12:44:01Z | |
dc.date.available | 2023-02-03T12:44:01Z | |
dc.date.issued | 2022 | |
dc.description.abstract | The development of synthetic non-equilibrium systems opens doors for man-made life-like materials. Yet, creating distinct transient functions from artificial fuel-driven structures remains a challenge. Building on our ATP-driven dynamic covalent DNA assembly in an enzymatic reaction network of concurrent ATP-powered ligation and restriction, we introduce ATP-fueled transient organization of functional subunits for various functions. The programmability of the ligation/restriction site allows to precisely organize multiple sticky-end-encoded oligo segments into double-stranded (ds) DNA complexes. We demonstrate principles of ATP-driven organization into sequence-defined oligomers by sensing barcode-embedded targets with different defects. Furthermore, ATP-fueled DNAzymes for substrate cleavage are achieved by transiently ligating two DNAzyme subunits into a dsDNA complex, rendering ATP-fueled transient catalytic function. | en_GB |
dc.description.sponsorship | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577 | de |
dc.identifier.doi | http://doi.org/10.25358/openscience-8761 | |
dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/8777 | |
dc.language.iso | eng | de |
dc.rights | CC-BY-NC-4.0 | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject.ddc | 540 Chemie | de_DE |
dc.subject.ddc | 540 Chemistry and allied sciences | en_GB |
dc.title | Dissipative organization of DNA oligomers for transient catalytic function | en_GB |
dc.type | Zeitschriftenaufsatz | de |
jgu.journal.issue | 10 | de |
jgu.journal.title | Angewandte Chemie : International edition | de |
jgu.journal.volume | 61 | de |
jgu.organisation.department | FB 09 Chemie, Pharmazie u. Geowissensch. | de |
jgu.organisation.name | Johannes Gutenberg-Universität Mainz | |
jgu.organisation.number | 7950 | |
jgu.organisation.place | Mainz | |
jgu.organisation.ror | https://ror.org/023b0x485 | |
jgu.pages.alternative | 202113477 | de |
jgu.publisher.doi | 10.1002/anie.202113477 | de |
jgu.publisher.issn | 1521-3773 | de |
jgu.publisher.name | Wiley-VCH | de |
jgu.publisher.place | Weinheim | de |
jgu.publisher.year | 2022 | |
jgu.rights.accessrights | openAccess | |
jgu.subject.ddccode | 540 | de |
jgu.subject.dfg | Naturwissenschaften | de |
jgu.type.contenttype | Scientific article | de |
jgu.type.dinitype | Article | en_GB |
jgu.type.resource | Text | de |
jgu.type.version | Published version | de |
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