Altered grey matter integrity and network vulnerability relate to epilepsy occurrence in patients with multiple sclerosis

dc.contributor.authorCiolac, Dumitru
dc.contributor.authorGonzalez-Escamilla, Gabriel
dc.contributor.authorWinter, Yaroslav
dc.contributor.authorMelzer, Nico
dc.contributor.authorLuessi, Felix
dc.contributor.authorRadetz, Angela
dc.contributor.authorFleischer, Vinzenz
dc.contributor.authorGroppa, Stanislav A.
dc.contributor.authorKirsch, Michael
dc.contributor.authorBittner, Stefan
dc.contributor.authorZipp, Frauke
dc.contributor.authorMuthuraman, Muthuraman
dc.contributor.authorMeuth, Sven G.
dc.contributor.authorGrothe, Matthias
dc.contributor.authorGroppa, Sergiu
dc.date.accessioned2023-01-17T11:33:01Z
dc.date.available2023-01-17T11:33:01Z
dc.date.issued2022
dc.description.abstractBackground and purpose The aim of this study was to investigate the relevance of compartmentalized grey matter (GM) pathology and network reorganization in multiple sclerosis (MS) patients with concomitant epilepsy. Methods From 3-T magnetic resonance imaging scans of 30 MS patients with epilepsy (MSE group; age 41 ± 15 years, 21 females, disease duration 8 ± 6 years, median Expanded Disability Status Scale [EDSS] score 3), 60 MS patients without epilepsy (MS group; age 41 ± 12 years, 35 females, disease duration 6 ± 4 years, EDSS score 2), and 60 healthy subjects (HS group; age 40 ± 13 years, 27 females) the regional volumes of GM lesions and of cortical, subcortical and hippocampal structures were quantified. Network topology and vulnerability were modelled within the graph theoretical framework. Receiver-operating characteristic (ROC) curve analysis was applied to assess the accuracy of GM pathology measures to discriminate between MSE and MS patients. Results Higher lesion volumes within the hippocampus, mesiotemporal cortex and amygdala were detected in the MSE compared to the MS group (all p < 0.05). The MSE group had lower cortical volumes mainly in temporal and parietal areas compared to the MS and HS groups (all p < 0.05). Lower hippocampal tail and presubiculum volumes were identified in both the MSE and MS groups compared to the HS group (all p < 0.05). Network topology in the MSE group was characterized by higher transitivity and assortativity, and higher vulnerability compared to the MS and HS groups (all p < 0.05). Hippocampal lesion volume yielded the highest accuracy (area under the ROC curve 0.80 [0.67–0.91]) in discriminating between MSE and MS patients. Conclusions High lesion load, altered integrity of mesiotemporal GM structures, and network reorganization are associated with a greater propensity for epilepsy occurrence in people with MS.en_GB
dc.description.sponsorshipGefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577de
dc.identifier.doihttp://doi.org/10.25358/openscience-8579
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8595
dc.language.isoengde
dc.rightsCC-BY-NC-ND-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleAltered grey matter integrity and network vulnerability relate to epilepsy occurrence in patients with multiple sclerosisen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.issue8de
jgu.journal.titleEuropean journal of neurologyde
jgu.journal.volume29de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end2320de
jgu.pages.start2309de
jgu.publisher.doi10.1111/ene.15405de
jgu.publisher.issn1468-1331de
jgu.publisher.nameWiley-Blackwellde
jgu.publisher.placeOxford u.a.de
jgu.publisher.year2022
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.subject.dfgLebenswissenschaftende
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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