Diagnostische Wertigkeit der optisch-spektralen Transmissionsbildgebung (HandScan) bei PatientInnen mit Arthritis: Assoziation mit MRT-Ergebnissen
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Abstract
Background
Optical spectral transmission (OST) is a modern diagnostic method capable of quantifying
inflammation in the finger and wrist joints of arthritis patients by assessing the blood-specific absorption of light
transmitted through a tissue. The diagnostic performance of this modality has not been adequately examined
and data regarding OST associations with magnetic resonance imaging (MRI) are limited. Aim of this study was
therefore to investigate the performance of OST in assessing joint inflammation as compared to MRI in patients with
inflammatory arthritis (IA).
Methods
Data from patients who underwent MRI and OST for suspected IA were analyzed. For comparison,
a historical healthy control (HC) group with OST was also accounted. MRI findings were quantified using the
Rheumatoid Arthritis MRI Score (RAMRIS). Diagnostic accuracy of OST was evaluated using Receiver Operating
Characteristics (ROC), while correlation analyses were conducted to explore relationships between OST and MRI, as
well as disease activity markers.
Results
Overall, 71 patients with known rheumatic diseases (n = 1,542 wrist and finger joints) and 114 HC (n = 2,508
joints) subjects were included. 51 patients showed inflammatory signs on MRI (MRI+). These also showed significantly
higher OST scores (16.41 ± 5.53) than subjects without MRI inflammation (MRI-) (11.52 ± 5.03) or HC (10.78 ± 4.19) (all;
p < 0.001). OST showed significant correlations with RAMRIS-synovitis and tenosynovitis scores in the MRI + group
(rho = 0.541, p < 0.001; rho = 0.341, p = 0.01, respectively). Significant correlations were observed between OST and
clinical parameters for disease activity. Using MRI as a reference, the best diagnostic value of OST was observed at the
wrist level in the MRI + group, by an AUC of 0.833 (95%CI 0.700-0.966).
Conclusion
OST showed an excellent performance compared to MRI and correlated significantly with RAMRIS scores
and clinical parameters in IA patients, also differentiating IA from HC.