Gutenberg Open Science: Resilience and stability of the CF- intestinal and respiratory microbiome during nutritional and exercise intervention

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9438

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DC Field	Value	Language
dc.contributor.author	Knoll, Rebecca L.	-
dc.contributor.author	Jarquín‑Díaz, Víctor Hugo	-
dc.contributor.author	Klopp, Jonas	-
dc.contributor.author	Kemper, Alissa	-
dc.contributor.author	Hilbert, Katja	-
dc.contributor.author	Hillen, Barlo	-
dc.contributor.author	Pfirrmann, Daniel	-
dc.contributor.author	Simon, Perikles	-
dc.contributor.author	Bähner, Viola	-
dc.contributor.author	Nitsche, Oliver	-
dc.contributor.author	Gehring, Stephan	-
dc.contributor.author	Markó, Lajos	-
dc.contributor.author	Forslund, Sofia K.	-
dc.contributor.author	Poplawska, Krystyna	-
dc.date.accessioned	2023-08-25T10:22:24Z	-
dc.date.available	2023-08-25T10:22:24Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/9456	-
dc.description.abstract	Background Impaired respiratory and intestinal microbiome composition is linked to cystic fibrosis lung disease severity. In people with cystic fibrosis (pwCF), regular exercise is recommended to delay disease progression and preserve a stable lung function. An optimal nutritional status is vital for best clinical outcomes. Our study investigated whether regular and monitored exercise and nutritional support promotes CF microbiome health. Methods A personalized nutrition and exercise program promoted nutritional intake and physical fitness in 18 pwCF for 12 months. Throughout the study, patients performed strength and endurance training monitored by a sports scientist via an internet platform. After three months, food supplementation with Lactobacillus rhamnosus LGG was introduced. Nutritional status and physical fitness were assessed before the study started, after three and nine months. Sputum and stool were collected, and microbial composition was analyzed by 16S rRNA gene sequencing. Results Sputum and stool microbiome composition remained stable and highly specific to each patient during the study period. Disease-associated pathogens dominated sputum composition. Lung disease severity and recent antibiotic treatment had the highest impact on taxonomic composition in stool and sputum microbiome. Strikingly, the long-term antibiotic treatment burden had only a minor influence. Conclusion Despite the exercise and nutritional intervention, respiratory and intestinal microbiomes proved to be resilient. Dominant pathogens drove the composition and functionality of the microbiome. Further studies are required to understand which therapy could destabilize the dominant disease-associated microbial composition of pwCF.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Resilience and stability of the CF- intestinal and respiratory microbiome during nutritional and exercise intervention	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-9438	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	BMC microbiology	de
jgu.journal.volume	23	de
jgu.pages.alternative	44	de
jgu.publisher.year	2023	-
jgu.publisher.name	BioMed Central	de
jgu.publisher.place	London	de
jgu.publisher.uri	https://doi.org/10.1186/s12866-023-02788-y	de
jgu.publisher.issn	1471-2180	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1186/s12866-023-02788-y	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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