Gutenberg Open Science: Electrochemical synthesis of pyrazolines and pyrazoles via [3+2] dipolar cycloaddition

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9314

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DC Field	Value	Language
dc.contributor.author	Linden, Martin	-
dc.contributor.author	Hofmann, Silja	-
dc.contributor.author	Herman, Antonia	-
dc.contributor.author	Ehler, Nicole	-
dc.contributor.author	Bär, Robin M.	-
dc.contributor.author	Waldvogel, Siegfried R.	-
dc.date.accessioned	2023-08-03T08:24:41Z	-
dc.date.available	2023-08-03T08:24:41Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/9332	-
dc.description.abstract	Pyrazolines and pyrazoles are common and important motifs of pharmaceutical agents and agrochemicals. Herein, the first electrochemical approach for their direct synthesis from easily accessible hydrazones and dipolarophiles up to decagram scale is presented. The application of a biphasic system (aqueous/organic) even allows for the conversion of highly sensitive alkenes, wherein inexpensive sodium iodide is employed in a dual role as supporting electrolyte and mediator. In addition, mechanistic insight into the reaction is given by the isolation of key step intermediates. The relevance of the presented reaction is underlined by the synthesis of commercial herbicide safener mefenpyr-diethyl in good yields.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.title	Electrochemical synthesis of pyrazolines and pyrazoles via [3+2] dipolar cycloaddition	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-9314	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Angewandte Chemie : international edition	de
jgu.journal.volume	62	de
jgu.journal.issue	9	de
jgu.pages.alternative	e202214820	de
jgu.publisher.year	2023	-
jgu.publisher.name	Wiley-VCH	de
jgu.publisher.place	Weinheim	de
jgu.publisher.issn	1521-3773	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.publisher.doi	10.1002/anie.202214820	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.relation.IsVersionOf	10.25358/openscience-10134	-
Appears in collections:	DFG-491381577-H

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