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  2. Johannes Gutenberg-Universität Mainz
  3. DFG-491381577-H
Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9052
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dc.contributor.authorBessler, Larissa-
dc.contributor.authorVogt, Lea-Marie-
dc.contributor.authorLander, Marc-
dc.contributor.authorDal Magro, Christina-
dc.contributor.authorKeller, Patrick-
dc.contributor.authorKühlborn, Jonas-
dc.contributor.authorKampf, Christopher J.-
dc.contributor.authorOpatz, Till-
dc.contributor.authorHelm, Mark-
dc.date.accessioned2023-04-27T08:34:43Z-
dc.date.available2023-04-27T08:34:43Z-
dc.date.issued2023-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/9069-
dc.description.abstractThe fields of RNA modification and RNA damage both exhibit a plethora of non-canonical nucleo side structures. While RNA modifications have evolved to improve RNA function, the term RNA damage implies detrimental effects. Based on stable isotope labelling and mass spectrometry, we report the identi fication and characterisation of 2-methylthio-1,N6-ethe noadenosine (ms2 ɛA), which is related to 1,N6-etheno adenine, a lesion resulting from exposure of nucleic acids to alkylating chemicals in vivo. In contrast, a sophisticated isoprene labelling scheme revealed that ms2 ɛA biogenesis involves cleavage of a prenyl moiety in the known transfer RNA (tRNA) modification 2-meth ylthio-N6-isopentenyladenosine (ms2 i 6 A). The relative abundance of ms2 ɛA in tRNAs from translating ribo somes suggests reduced function in comparison to its parent RNA modification, establishing the nature of the new structure in a newly perceived overlap of the two previously separate fields, namely an RNA modification damage.en_GB
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin-
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleA new bacterial adenosine-derived nucleoside as an example of RNA modification damageen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-9052-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.de
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleAngewandte Chemie : International editionde
jgu.journal.volume62de
jgu.journal.issue11de
jgu.pages.alternativee202217128de
jgu.publisher.year2023-
jgu.publisher.nameWiley-VCHde
jgu.publisher.placeWeinheimde
jgu.publisher.issn1521-3773de
jgu.organisation.placeMainz-
jgu.subject.ddccode540de
dc.date.updated2023-04-25T09:34:14Z-
jgu.publisher.licenceCC BY-
jgu.publisher.doi10.1002/anie.202217128de
elements.object.id152651-
elements.object.labelsEpitranscriptome-
elements.object.labelsIsotopic Labeling-
elements.object.labelsMass Spectrometry-
elements.object.labelsNucleoside Analysis-
elements.object.labelsRNA Modification Damage-
elements.object.labelsNucleosides-
elements.object.labelsRNA-
elements.object.labelsRNA, Bacterial-
elements.object.labelsRNA, Transfer-
elements.object.labelsAdenosine-
elements.object.labelsEpitranscriptome-
elements.object.labelsIsotopic Labeling-
elements.object.labelsMass Spectrometry-
elements.object.labelsNucleoside Analysis-
elements.object.labelsRNA Modification Damage-
elements.object.labelsNucleosides-
elements.object.labelsAdenosine-
elements.object.labelsRNA, Transfer-
elements.object.labelsRNA-
elements.object.labelsRNA, Bacterial-
elements.object.labels03 Chemical Sciences-
elements.object.labelsOrganic Chemistry-
elements.object.labels34 Chemical sciences-
elements.object.typejournal-article-
jgu.organisation.rorhttps://ror.org/023b0x485-
jgu.relation.IsVersionOf10.25358/openscience-10177-
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