Gutenberg Open Science: Insertion of 3D DNA origami nanopores into block copolymer vesicles

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8715

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DC Field	Value	Language
dc.contributor.author	Groeer, Saskia	-
dc.contributor.author	Garni, Martina	-
dc.contributor.author	Samanta, Avik	-
dc.contributor.author	Walther, Andreas	-
dc.date.accessioned	2023-02-02T10:52:09Z	-
dc.date.available	2023-02-02T10:52:09Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8731	-
dc.description.abstract	Block copolymer-based polymersomes are important building blocks for the bottom-up design of protocells and are considered advantageous over liposomes due to their higher mechanical stability and chemical versatility. Endowing both types of vesicles with capabilities for transmembrane transport is important for creating nanoreactor functionality and has been achieved by insertion of protein nanopores, even into comparably thick polymersome membranes. Still, the design space for protein nanopores is limited and higher flexibility might be accessible by de novo design of DNA nanopores, which have thus far been limited largely to liposome systems. Here, we introduce the successful insertion of two different 3D DNA origami nanopores into PMOXA-b-PDMS-b-PMOXA polymersomes, and confirm pore formation by dye influx studies and microscopy. This research thus opens the further design space of this versatile class of large DNA origami nanopores for polymersome-based functional protocells.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) – Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.title	Insertion of 3D DNA origami nanopores into block copolymer vesicles	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8715	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	ChemSystemsChem	de
jgu.journal.volume	4	de
jgu.journal.issue	6	de
jgu.pages.alternative	202200009	de
jgu.publisher.year	2022	-
jgu.publisher.name	John Wiley & Sons, Ltd	de
jgu.publisher.place	Weinheim	de
jgu.publisher.issn	25704206	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.publisher.doi	10.1002/syst.202200009	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Naturwissenschaften	de
Appears in collections:	DFG-491381577-H

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