Gutenberg Open Science: Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8617

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DC Field	Value	Language
dc.contributor.author	Karl, Martin	-
dc.contributor.author	Hasselwander, Solveig	-
dc.contributor.author	Zhou, Yawen	-
dc.contributor.author	Reifenberg, Gisela	-
dc.contributor.author	Kim, Yong Ook	-
dc.contributor.author	Park, Kyoung-Sook	-
dc.contributor.author	Ridder, Dirk A.	-
dc.contributor.author	Wang, Xiaoyu	-
dc.contributor.author	Seidel, Eric	-
dc.contributor.author	Hövelmeyer, Nadine	-
dc.contributor.author	Straub, Beate K.	-
dc.contributor.author	Li, Huige	-
dc.contributor.author	Schuppan, Detlef	-
dc.contributor.author	Xia, Ning	-
dc.date.accessioned	2023-01-20T11:25:19Z	-
dc.date.available	2023-01-20T11:25:19Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8633	-
dc.description.abstract	Background and Aims Growing evidence suggests an important role of B cells in the development of NAFLD. However, a detailed functional analysis of B cell subsets in NAFLD pathogenesis is lacking. Approach and Results In wild-type mice, 21 weeks of high fat diet (HFD) feeding resulted in NAFLD with massive macrovesicular steatosis, modest hepatic and adipose tissue inflammation, insulin resistance, and incipient fibrosis. Remarkably, Bnull (JHT) mice were partially protected whereas B cell harboring but antibody-deficient IgMi mice were completely protected from the development of hepatic steatosis, inflammation, and fibrosis. The common feature of JHT and IgMi mice is that they do not secrete antibodies, whereas HFD feeding in wild-type mice led to increased levels of serum IgG2c. Whereas JHT mice have no B cells at all, regulatory B cells were found in the liver of both wild-type and IgMi mice. HFD reduced the number of regulatory B cells and IL-10 production in the liver of wild-type mice, whereas these increased in IgMi mice. Livers of patients with advanced liver fibrosis showed abundant deposition of IgG and stromal B cells and low numbers of IL-10 expressing cells, compatible with our experimental data. Conclusions B lymphocytes have both detrimental and protective effects in HFD-induced NAFLD. The lack of secreted pathogenic antibodies protects partially from NAFLD, whereas the presence of certain B cell subsets provides additional protection. IL-10–producing regulatory B cells may represent such a protective B cell subset.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8617	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Hepatology	de
jgu.journal.volume	76	de
jgu.journal.issue	4	de
jgu.pages.start	1135	de
jgu.pages.end	1149	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley Interscience	de
jgu.publisher.place	New York, NY u.a.	de
jgu.publisher.issn	1527-3350	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1002/hep.32428	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

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