Gutenberg Open Science: CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8586

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DC Field	Value	Language
dc.contributor.author	Hetsch, Florian	-
dc.contributor.author	Wang, Danni	-
dc.contributor.author	Chen, Xufeng	-
dc.contributor.author	Zhang, Jiong	-
dc.contributor.author	Aslam, Muhammad	-
dc.contributor.author	Kegel, Marcel	-
dc.contributor.author	Tonner, Henrik	-
dc.contributor.author	Grus, Franz	-
dc.contributor.author	Engelhardt, Jakob von	-
dc.date.accessioned	2023-01-19T09:04:07Z	-
dc.date.available	2023-01-19T09:04:07Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8602	-
dc.description.abstract	Relay neurons of the dorsal lateral geniculate nucleus (dLGN) receive inputs from retinal ganglion cells via retinogeniculate synapses. These connections undergo pruning in the first 2 weeks after eye opening. The remaining connections are strengthened several-fold by the insertion of AMPA receptors (AMPARs) into weak or silent synapses. In this study, we found that the AMPAR auxiliary subunit CKAMP44 is required for receptor insertion and function of retinogeniculate synapses during development. Genetic deletion of CKAMP44 resulted in decreased synaptic strength and a higher number of silent synapses in young (P9–11) mice. Recovery from desensitisation of AMPARs was faster in CKAMP44 knockout (CKAMP44–/–) than in wild-type mice. Moreover, loss of CKAMP44 increased the probability of inducing plateau potentials, which are known to be important for eye-specific input segregation and retinogeniculate synapse maturation. The anatomy of relay neurons in the dLGN was changed in young CKAMP44–/– mice showing a transient increase in dendritic branching that normalised during later development (P26–33). Interestingly, input segregation in young CKAMP44–/– mice was not affected when compared to wild-type mice. These results demonstrate that CKAMP44 promotes maturation and modulates function of retinogeniculate synapses during early development of the visual system without affecting input segregation.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8586	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	The journal of physiology	de
jgu.journal.volume	600	de
jgu.journal.issue	15	de
jgu.pages.start	3549	de
jgu.pages.end	3565	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Hoboken, NJ	de
jgu.publisher.issn	1469-7793	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1113/JP283172	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

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