Gutenberg Open Science: The role of preterm birth, retinopathy of prematurity and perinatal factors on corneal aberrations in adulthood : results from the Gutenberg prematurity eye study

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8582

Full metadata record

DC Field	Value	Language
dc.contributor.author	Fieß, Achim	-
dc.contributor.author	Berger, Lina Amalia	-
dc.contributor.author	Riedl, Jana C.	-
dc.contributor.author	Mildenberger, Eva	-
dc.contributor.author	Urschitz, Michael S.	-
dc.contributor.author	Hampel, Ulrike	-
dc.contributor.author	Wasielica-Poslednik, Joanna	-
dc.contributor.author	Zepp, Fred	-
dc.contributor.author	Stoffelns, Bernahrd	-
dc.contributor.author	Pfeiffer, Norbert	-
dc.contributor.author	Schuster, Alexander K.	-
dc.date.accessioned	2023-01-18T09:50:49Z	-
dc.date.available	2023-01-18T09:50:49Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8598	-
dc.description.abstract	Introduction Prematurity and retinopathy of prematurity (ROP) are associated with altered corneal shape and reduced visual acuity in childhood, but their long-term effects on corneal shape in later life are still unclear. This study evaluated whether prematurity and related perinatal factors are associated with corneal aberrations in adulthood. Methods The Gutenberg Prematurity Eye Study (GPES) is a cohort study using Scheimpflug imaging of the cornea. Associations were assessed between corneal Zernike aberrations and gestational age (GA), birth weight (BW), BW percentile, ROP occurrence, ROP treatment and other perinatal factors using univariate and multivariable linear regression analyses. Results This study involved 444 eyes of 256 individuals born preterm (aged 28.1 ± 8.4 years, 146 females) and 231 eyes of 132 individuals born full-term (aged 29.8 ± 8.9 years, 77 females). Multivariable analyses revealed an association between corneal higher-order aberrations and lower birth weight percentile (B = −0.001, p < 0.001) as well as ROP treatment (B = 0.120, p = 0.03). Corneal lower-order aberrations were also associated with lower birth weight percentile (B = −0.004; p = 0.001) and ROP treatment (B = 0.838, p = 0.01) but not with ROP occurrence. Increased corneal aberrations were correlated with lower visual acuity and the spherical equivalent refractive error. Conclusions Perinatal factors, particularly low birth weight percentile and ROP treatment lead to a more irregular corneal shape in adulthood, thereby reducing optical image quality and potentially contributing to reduced visual acuity and altered refractive error.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	The role of preterm birth, retinopathy of prematurity and perinatal factors on corneal aberrations in adulthood : results from the Gutenberg prematurity eye study	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8582	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Ophthalmic and physiological optics	de
jgu.journal.volume	42	de
jgu.journal.issue	6	de
jgu.pages.start	1379	de
jgu.pages.end	1389	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford u.a	de
jgu.publisher.issn	1475-1313	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/opo.13038	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

Files in This Item:

	File	Description	Size	Format
	the_role_of_preterm_birth_ret-20230118104707493.pdf		1.85 MB	Adobe PDF	View/Open

Show simple item record