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Authors: Varga-Szemes, Akos
Halfmann, Moritz
Schoepf, Joseph
Jin, Ning
Kilburg, Anton
Dargis, Danielle M.
Düber, Christoph
Ese, Amir
Aquino, Gilberto
Xiong, Fei
Kreitner, Karl-Friedrich
Markl, Michael
Emrich, Tilman
Title: Highly accelerated compressed-sensing 4D flow for intracardiac flow assessment
Online publication date: 19-Jan-2023
Year of first publication: 2022
Language: english
Abstract: Background: Four-dimensional (4D) flow MRI allows for the quantification of complex flow patterns; however, its clinical use is limited by its inherently long acquisition time. Compressed sensing (CS) is an acceleration technique that provides substantial reduction in acquisition time. Purpose: To compare intracardiac flow measurements between conventional and CS-based highly accelerated 4D flow acquisitions. Study Type: Prospective. Subjects: Fifty healthy volunteers (28.0 7.1 years, 24 males). Field Strength/Sequence: Whole heart time-resolved 3D gradient echo with three-directional velocity encoding (4D flow) with conventional parallel imaging (factor 3) as well as CS (factor 7.7) acceleration at 3 T. Assessment: 4D flow MRI data were postprocessed by applying a valve tracking algorithm. Acquisition times, flow vol umes (mL/cycle) and diastolic function parameters (ratio of early to late diastolic left ventricular peak velocities [E/A] and ratio of early mitral inflow velocity to mitral annular early diastolic velocity [E/e0 ]) were quantified by two readers. Statistical Tests: Paired-samples t-test and Wilcoxon rank sum test to compare measurements. Pearson correlation coeffi cient (r), Bland–Altman-analysis (BA) and intraclass correlation coefficient (ICC) to evaluate agreement between techniques and readers. A P value < 0.05 was considered statistically significant. Results: A significant improvement in acquisition time was observed using CS vs. conventional accelerated acquisition (6.7 1.3 vs. 12.0 1.3 min). Net forward flow measurements for all valves showed good correlation (r > 0.81) and agree ment (ICCs > 0.89) between conventional and CS acceleration, with 3.3%–8.3% underestimation by the CS technique. Evaluation of diastolic function showed 3.2%–17.6% error: E/A 2.2 [1.9–2.4] (conventional) vs. 2.3 [2.0–2.6] (CS), BA bias 0.08 [ 0.81–0.96], ICC 0.82; and E/e0 4.6 [3.9–5.4] (conventional) vs. 3.8 [3.4–4.3] (CS), BA bias 0.90 [ 2.31–0.50], ICC 0.89. Data Conclusion: Analysis of intracardiac flow patterns and evaluation of diastolic function using a highly accelerated 4D flow sequence prototype is feasible, but it shows underestimation of flow measurements by approximately 10%. Evidence Level: 2 Technical Efficacy: Stage 1
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC-ND
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Journal: Journal of magnetic resonance imaging
Version of Record (VoR)
Publisher: Wiley-Liss
Publisher place: New York, NY
Issue date: 2022
ISSN: 1522-2586
Publisher DOI: 10.1002/jmri.28484
Appears in collections:DFG-491381577-H

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