Gutenberg Open Science: Novel concept of CD4-mediated activation of regulatory T cells for the treatment of graft-versus-host disease

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8140

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DC Field	Value	Language
dc.contributor.author	Schlöder, Janine	-
dc.contributor.author	Berges, Carsten	-
dc.contributor.author	Tüttenberg, Andrea	-
dc.contributor.author	Jonuleit, Helmut	-
dc.date.accessioned	2022-10-21T07:26:09Z	-
dc.date.available	2022-10-21T07:26:09Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8155	-
dc.description.abstract	Allogeneic hematopoietic stem cell transplantation (aHSCT) is the only curative treatment option for several hematological malignancies and immune deficiency syndromes. Nevertheless, the development of a graft-versus-host-disease (GvHD) after transplantation is a high risk and a severe complication with high morbidity and mortality causing therapeutic challenges. Current pharmacological therapies of GvHD lead to generalized immunosuppression followed by severe adverse side effects including infections and relapse of leukemia. Several novel cell-based immunomodulatory strategies for treatment or prevention of GvHD have been developed. Herein, thymus-derived regulatory T cells (tTreg), essential for the maintenance of peripheral immunologic tolerance, are in the focus of investigation. However, due to the limited number of tTreg in the peripheral blood, a complex, time and cost intensive in vitro expansion protocol is necessary for the production of an efficient cellular therapeutic. We demonstrated that activation of tTreg using the CD4-binding HIV-1 protein gp120 leads to a substantially increased suppressor activity of tTreg without the need for additional expansion. Gp120-activated tTreg prevent GvHD development in a preclinical humanized mouse model. In addition, gp120 is not only effective in prevention but also in therapy of GvHD by suppressing all clinical symptoms and improving survival of treated mice. These data indicate that tTreg activation by gp120 is a feasible and potent strategy for significant functional improvement of tTreg as cellular therapeutic for GvHD treatment without the need of complicated, time intensive and expensive in vitro expansion of isolated tTreg.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Novel concept of CD4-mediated activation of regulatory T cells for the treatment of graft-versus-host disease	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8140	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Frontiers in immunology	de
jgu.journal.volume	8	de
jgu.pages.alternative	Art. 1495	de
jgu.publisher.year	2017	-
jgu.publisher.name	Frontiers Media	de
jgu.publisher.place	Lausanne	de
jgu.publisher.uri	http://dx.doi.org/10.3389/fimmu.2017.01495	de
jgu.publisher.issn	1664-3224	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-03-23T11:16:06Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Hautklinik	de_DE
opus.identifier.opusid	57998
opus.institute.number	0431
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Schlöder, Janine
opus.affiliated	Tüttenberg, Andrea
opus.affiliated	Jonuleit, Helmut
jgu.publisher.doi	10.3389/fimmu.2017.01495	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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