Gutenberg Open Science: Multicomponent encapsulation into protein nanocarriers for co-delivery of therapeutics

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8091

Full metadata record

DC Field	Value	Language
dc.contributor.author	Hüppe, Natkritta	-
dc.date.accessioned	2023-02-15T15:01:18Z	-
dc.date.available	2023-02-15T15:01:18Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8106	-
dc.description.abstract	Successful tumor vaccination relies on a strong and durable immune response. Common soluble vaccine formulations lack the efficiency for sufficient stimulation of immune cells against tumor cells. This thesis presents the development of a multifunctional nanocarrier to enhance immune cell stimulation and tumor vaccination. The biocompatible and degradable protein nanocapsules are formed through an interfacial crosslinking via a metal-free azide-alkyne click in an inverse miniemulsion. This allows a multicomponent encapsulation of adjuvants into protein nanocapsules with high efficiency, controlled concentration and without affecting the activity of the cargo molecules. The protein nanocapsules could be functionalized on the surface with stealth and targeting moieties to enhance the specific uptake into dendritic cells.	en_GB
dc.language.iso	eng	de
dc.rights	InCopyright	*
dc.rights.uri	http://rightsstatements.org/vocab/InC/1.0/	*
dc.subject.ddc	500 Naturwissenschaften	de_DE
dc.subject.ddc	500 Natural sciences and mathematics	en_GB
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Multicomponent encapsulation into protein nanocarriers for co-delivery of therapeutics	en_GB
dc.type	Dissertation	de
dc.identifier.urn	urn:nbn:de:hebis:77-openscience-6c4973fe-6864-48e8-ab8b-4a5356a8da822	-
dc.identifier.doi	http://doi.org/10.25358/openscience-8091	-
jgu.type.dinitype	doctoralThesis	en_GB
jgu.type.version	Original work	de
jgu.type.resource	Text	de
jgu.date.accepted	2022-10-06	-
jgu.description.extent	xiv, 220 Seiten	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.department	Sonderforschungsbereiche (SFB)	de
jgu.organisation.number	7950	-
jgu.organisation.number	8570	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	500	de
jgu.subject.ddccode	540	de
jgu.subject.ddccode	610	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

Files in This Item:

	File	Description	Size	Format
	multicomponent_encapsulation_-20221021152100104.pdf		13.55 MB	Adobe PDF	View/Open

Show simple item record