Gutenberg Open Science: Dimethyl fumarate therapy significantly improves the responsiveness of T cells in multiple sclerosis patients for immunoregulation by regulatory T cells

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8060

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DC Field	Value	Language
dc.contributor.author	Schlöder, Janine	-
dc.contributor.author	Berges, Carsten	-
dc.contributor.author	Lüssi, Felix	-
dc.contributor.author	Jonuleit, Helmut	-
dc.date.accessioned	2022-10-17T07:55:58Z	-
dc.date.available	2022-10-17T07:55:58Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8075	-
dc.description.abstract	Multiple sclerosis (MS) is a chronic autoimmune disease caused by an insufficient suppression of autoreactive t lymphocytes. one reason for the lack of immunological control is the reduced responsiveness of t effector cells (teff) for the suppressive properties of regulatory t cells (treg), a process termed treg resistance. here we investigated whether the disease-modifying therapy of relapsing-remitting ms (rrms) with dimethyl fumarate (dmf) influences the sensitivity of t cells in the peripheral blood of patients towards treg-mediated suppression. we demonstrated that dmf restores responsiveness of teff to the suppressive function of treg in vitro, presumably by down-regulation of interleukin-6r (il-6r) expression on t cells. transfer of human immune cells into immunodeficient mice resulted in a lethal graft-versus-host reaction triggered by human cd4+ teff. this systemic inflammation can be prevented by activated treg after transfer of immune cells from dmf-treated ms patients, but not after injection of treg-resistant teff from therapy-naïve ms patients. furthermore, after dmf therapy, proliferation and expansion of t cells and the immigration into the spleen of the animals is reduced and modulated by activated treg. in summary, our data reveals that dmf therapy significantly improves the responsiveness of teff in ms patients to immunoregulation.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Dimethyl fumarate therapy significantly improves the responsiveness of T cells in multiple sclerosis patients for immunoregulation by regulatory T cells	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8060	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	International journal of molecular sciences	de
jgu.journal.volume	18	de
jgu.journal.issue	2	de
jgu.pages.alternative	Art. 271	de
jgu.publisher.year	2017	-
jgu.publisher.name	Molecular Diversity Preservation International	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	http://dx.doi.org/10.3390/ijms18020271	de
jgu.publisher.issn	1422-0067	de
jgu.publisher.issn	1661-6596	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-03-23T11:08:09Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Hautklinik	de_DE
opus.organisation.string	FB 04: Medizin: Klinik und Poliklinik für Neurologie	de_DE
opus.identifier.opusid	57997
opus.institute.number	0431
opus.institute.number	0435
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Schlöder, Janine
opus.affiliated	Lüssi, Felix
opus.affiliated	Jonuleit, Helmut
jgu.publisher.doi	10.3390/ijms18020271	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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