Gutenberg Open Science: Interferon-γ-dependent control of Anaplasma phagocytophilum by murine neutrophil granulocytes

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8045

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DC Field	Value	Language
dc.contributor.author	Gussmann, Kathrin	-
dc.contributor.author	Kirschnek, Susanne	-
dc.contributor.author	Loewenich, Friederike von	-
dc.date.accessioned	2022-10-17T06:49:20Z	-
dc.date.available	2022-10-17T06:49:20Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8060	-
dc.description.abstract	Anaplasma phagocytophilum is a Gram-negative obligate intracellular bacterium that is transmitted by ticks of the Ixodes ricinus complex. It replicates in neutrophils and elicits febrile disease in humans and animals. Because of its striking tropism for neutrophils, A. phagocytophilum has been used as a model organism to study the immune response against obligate intracellular pathogens. In mice, the control of A. phagocytophilum in the early phase of infection is dependent on natural killer cell-derived interferon-γ (IFN-γ). In contrast, the final elimination strictly requires CD4+ T-cells. It is a matter of debate, whether neutrophils serve only as host cells or as killer cells as well.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Interferon-γ-dependent control of Anaplasma phagocytophilum by murine neutrophil granulocytes	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8045	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Parasites & vectors	de
jgu.journal.volume	10	de
jgu.pages.alternative	Art. 329	de
jgu.publisher.year	2017	-
jgu.publisher.name	BioMed Central	de
jgu.publisher.place	London	de
jgu.publisher.uri	http://dx.doi.org/10.1186/s13071-017-2274-6	de
jgu.publisher.issn	1756-3305	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2019-01-15T09:04:44Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Medizinische Mikrobiologie und Hygiene	de_DE
opus.identifier.opusid	58006
opus.institute.number	0408
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Loewenich, Friederike von
jgu.publisher.doi	10.1186/s13071-017-2274-6	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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