Gutenberg Open Science: The development of vaccines from synthetic tumor-associated mucin glycopeptides and their glycosylation-dependent immune response

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8025

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DC Field	Value	Language
dc.contributor.author	Stergiou, Natascha	-
dc.contributor.author	Urschbach, Moritz	-
dc.contributor.author	Gabba, Adele	-
dc.contributor.author	Schmitt, Edgar	-
dc.contributor.author	Kunz, Horst	-
dc.contributor.author	Besenius, Pol	-
dc.date.accessioned	2022-10-24T10:22:30Z	-
dc.date.available	2022-10-24T10:22:30Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8040	-
dc.description.abstract	Tumor-associated carbohydrate antigens are overexpressed as altered-self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti-cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vaccines. By bridging synthetic chemistry and immunology, we discuss efforts in designing synthetic MUC1/4/16 vaccines and focus on the role of glycosylation patterns. We provide a brief introduction into the mechanisms of the immune system and aim to promote the development of cancer subunit vaccines.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.title	The development of vaccines from synthetic tumor-associated mucin glycopeptides and their glycosylation-dependent immune response	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8025	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	The chemical record	de
jgu.journal.volume	21	de
jgu.journal.issue	11	de
jgu.pages.start	3313	de
jgu.pages.end	3331	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley	de
jgu.publisher.place	New York, NY	de
jgu.publisher.issn	1528-0691	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.publisher.doi	10.1002/tcr.202100182	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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