Gutenberg Open Science: Reduced D2/D3 receptor binding of extrastriatal and striatal regions in temporal lobe epilepsy

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7998

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DC Field	Value	Language
dc.contributor.author	Bernedo Paredes, Viviane E.	-
dc.contributor.author	Buchholz, Hans-Georg	-
dc.contributor.author	Gartenschläger, Martin	-
dc.contributor.author	Breimhorst, Markus	-
dc.contributor.author	Schreckenberger, Mathias	-
dc.contributor.author	Werhahn, Konrad J.	-
dc.date.accessioned	2022-10-14T07:14:17Z	-
dc.date.available	2022-10-14T07:14:17Z	-
dc.date.issued	2015
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8013	-
dc.description.abstract	OBJECTIVE: Dopamine is an endogenous neuromodulator in cortical circuits and the basal ganglia. In animal models of temporal lobe epilepsy (TLE), seizure threshold is modulated to some extent by dopamine, with D1-receptors having a pro- and D2-receptors an anticonvulsant effect. We aimed to extend our previously reported results on decreased D2/D3 receptor binding in the lateral epileptogenic temporal lobe and to correlate them with demographic and seizure variables to gain a more comprehensive understanding of the underlying involvement of the dopaminergic system in the epileptogenesis of TLE. METHODS: To quantify D2/D3 receptor binding, we studied 21 patients with TLE and hippocampal sclerosis (13 left- and eight right-sided) and 18 controls using PET with the high-affinity dopamine D2/D3-receptor ligand 18F-Fallypride to image striatal and extrastriatal binding. TLE was defined by interictal and ictal video-EEG, MRI and 18F-Fluorodeoxyglucose PET. Voxel-based statistical and regions-of-interest analyses were performed. RESULTS: 18F-Fallypride binding potential was significantly reduced in the affected temporal lobe and bilateral putamen. A positive correlation between age at onset of epilepsy and [18F]FP BPnd (binding potential non-displaceable) in temporal regions on the epileptogenic side was found, as well as a negative correlation between epilepsy duration and [18F]FP BPnd in the temporal pole on the epileptogenic side and a positive correlation between the estimated number of lifetime GTCS and [18F]FP BPnd in the hippocampus on the epileptogenic side. SIGNIFICANCE: The areas of reduced D2/D3 receptor availability correspond to “the irritative zone” surrounding the epileptogenic area. Moreover, reduced D2/D3 receptor availability was detectable in the basal ganglia, which are suspected to be involved in a control circuit for epileptic seizures. The correlational analysis additionally suggests that increased epilepsy duration leads to increasing impairment of the dopaminergic system.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Reduced D2/D3 receptor binding of extrastriatal and striatal regions in temporal lobe epilepsy	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7998	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS one	de
jgu.journal.volume	10	de
jgu.journal.issue	11	de
jgu.pages.alternative	e0141098	de
jgu.publisher.year	2015	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, Kan.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0141098	de
jgu.publisher.issn	1932-6203	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2017-05-09T14:28:07Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie	de_DE
opus.organisation.string	FB 04: Medizin: Klinik und Poliklinik für Nuklearmedizin	de_DE
opus.identifier.opusid	53365
opus.institute.number	0419
opus.institute.number	0422
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Buchholz, Hans-Georg
opus.affiliated	Gartenschläger, Martin
opus.affiliated	Schreckenberger, Mathias
jgu.publisher.doi	10.1371/journal.pone.0141098	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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